MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mult Scler. 2024 Oct;30(11-12):1556-1560. doi: 10.1177/13524585241260968. Epub 2024 Jun 13.
Cortical lesion subtypes' occurrence and distribution across networks may shed light on cognitive impairment (CI) in multiple sclerosis (MS).
In 332 people with MS, lesions were classified as intracortical, leukocortical or juxtacortical based on artificially generated double inversion-recovery images.
CI-related leukocortical lesion count increases were greatest within sensorimotor and cognitive networks ( < 0.001). Only intracortical lesion count could distinguish between cognitive groups ( = 0.024). Effect sizes were two- to four-fold larger than differences between MS phenotypes.
In CI-MS, leukocortical lesions predominate, whereas intracortical lesions distinguish cognitive groups. Lesions' grey matter (GM) involvement might be decisive for cognition in MS, surpassing overall disease burden.
皮质病变亚型在网络中的发生和分布可能揭示多发性硬化症（MS）中的认知障碍（CI）。
在 332 名 MS 患者中，根据人工生成的双反转恢复图像将病变分为皮质内、白质内或皮质下。
与 CI 相关的白质内病变计数在感觉运动和认知网络中增加最多（<0.001）。只有皮质内病变计数才能区分认知组（=0.024）。效应大小是 MS 表型之间差异的两到四倍。
在 CI-MS 中，白质内病变占主导地位，而皮质内病变区分认知组。病变的灰质（GM）受累可能对 MS 中的认知至关重要，超过了整体疾病负担。
