Human Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive, Science Institute, Guangdong Provincial Fertility Hospital, Guangzhou, Guangdong, China.
Cancer Med. 2024 Jun;13(11):e7354. doi: 10.1002/cam4.7354.
According to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater than 5 years; however, long-term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents with cancer in China was initiated late, and related research is lacking. Analyze data to understand the current situation and implement measures to improve current practices.
From 2011 to 2020, data on 275 male adolescents with cancer whose age ranged from 0 to 19 years old were collected from 16 human sperm banks for this retrospective study. Methods include comparing the basic situation of male adolescents with cancer, the distribution of cancer types, and semen quality to analyze the status of fertility preservation.
The mean age was 17.39 ± 1.46 years, with 13 cases (4.7%) aged 13-14 years and 262 cases (95.3%) aged 15-19 years. Basic diagnoses included leukemia (55 patients), lymphomas (76), germ cell and gonadal tumors (65), epithelial tumors (37), soft tissue sarcomas (14), osteosarcoma (7), brain tumors (5), and other cancers (16). There are differences in tumor types in different age stages and regions. The tumor type often affects semen quality, while age affects semen volume. Significant differences were found in sperm concentration and progressive motility before and after treatment (p < 0.001). Moreover, 90.5% of patients had sperm in their semen and sperm were frozen successfully in 244 patients (88.7%).
The aim of this study is to raise awareness of fertility preservation in male adolescents with cancer, to advocate for fertility preservation prior to gonadotoxic therapy or other procedures that may impair future fertility, and to improve the fertility status of future patients.
根据研究，超过 80%的儿科癌症患者的生存率大于 5 年；然而，长期的化疗和/或放疗可能会严重影响他们的生殖能力。中国青少年癌症患者的生育力保存起步较晚，相关研究也较少。分析数据以了解现状并采取措施改善现状。
本回顾性研究收集了 2011 年至 2020 年来自 16 个人类精子库的 275 名年龄在 0 至 19 岁的男性青少年癌症患者的数据。方法包括比较男性青少年癌症患者的基本情况、癌症类型分布和精液质量，以分析生育力保存的现状。
平均年龄为 17.39±1.46 岁，其中 13 例（4.7%）年龄为 13-14 岁，262 例（95.3%）年龄为 15-19 岁。基本诊断包括白血病（55 例）、淋巴瘤（76 例）、生殖细胞和性腺肿瘤（65 例）、上皮肿瘤（37 例）、软组织肉瘤（14 例）、骨肉瘤（7 例）、脑肿瘤（5 例）和其他癌症（16 例）。不同年龄阶段和地区的肿瘤类型存在差异。肿瘤类型常影响精液质量，而年龄影响精液量。治疗前后精子浓度和前向运动精子的差异有统计学意义（p<0.001）。此外，90.5%的患者精液中有精子，244 例（88.7%）患者精子成功冷冻。
本研究旨在提高对男性青少年癌症患者生育力保存的认识，倡导在性腺毒性治疗或其他可能损害未来生育力的治疗前进行生育力保存，并改善未来患者的生育状况。
