Rubinstein I, Langevitz P, Shibi G
Oncology. 1985;42(2):104-6. doi: 10.1159/000226010.
We report a case of isolated malignant lymphoma of the jejunum occurring 18 18 months after continuous diphenylhydantoin therapy for epilepsy. Although this association may be purely coincidental, we suggest a possible causal relationship between the two in light of current knowledge about the immunological aberrations that may be caused by prolonged administration of diphenylhydantoin in man.
我们报告一例空肠孤立性恶性淋巴瘤病例，该病例发生在患者因癫痫接受苯妥英连续治疗18个月之后。尽管这种关联可能纯属巧合，但鉴于目前关于长期服用苯妥英可能导致人体免疫异常的知识，我们认为两者之间可能存在因果关系。
