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Comparison of the protective effects of chitosan oligosaccharides and chitin oligosaccharide on apoptosis, inflammation and oxidative stress.

作者信息

Li Qiongyu, Shi Wan-Rong, Huang Yun-Lin

机构信息

College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, Fujian 362000, P.R. China.

出版信息

Exp Ther Med. 2024 Jun 5;28(2):310. doi: 10.3892/etm.2024.12600. eCollection 2024 Aug.

DOI:10.3892/etm.2024.12600
PMID:38873041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11170321/
Abstract

Chitin degradation products, especially chitosan oligosaccharides (COSs), are highly valued in various industrial fields, such as food, medicine, cosmetics and agriculture, for their rich resources and high cost-effectiveness. However, little is known about the impact of acetylation on COS cellular bioactivity. The present study aimed to compare the differential effects of COS and highly N-acetylated COS (NACOS), known as chitin oligosaccharide, on HO-induced cell stress. MTT assay showed that pretreatment with NACOS and COS markedly inhibited HO-induced RAW264.7 cell death in a concentration-dependent manner. Flow cytometry indicated that NACOS and COS exerted an anti-apoptosis effect on HO-induced oxidative damage in RAW264.7 cells. NACOS and COS treatment ameliorated HO-induced RAW264.7 cell cycle arrest. Western blotting revealed that the anti-oxidation effects of NACOS and COS were mediated by suppressing expression of proteins involved in HO-induced apoptosis, including Bax, Bcl-2 and cleaved PARP. Furthermore, the antagonist effects of NACOS were greater than those of COS, suggesting that acetylation was essential for the protective effects of COS.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/7cfbf0f078af/etm-28-02-12600-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/f134b46c4b66/etm-28-02-12600-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/3be0ddf371ce/etm-28-02-12600-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/4076ede75627/etm-28-02-12600-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/7cfbf0f078af/etm-28-02-12600-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/f134b46c4b66/etm-28-02-12600-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/3be0ddf371ce/etm-28-02-12600-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/4076ede75627/etm-28-02-12600-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b79/11170321/7cfbf0f078af/etm-28-02-12600-g03.jpg

相似文献

[1]
Comparison of the protective effects of chitosan oligosaccharides and chitin oligosaccharide on apoptosis, inflammation and oxidative stress.

Exp Ther Med. 2024-6-5

[2]
Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway.

Neurotox Res. 2021-12

[3]
Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death via Bcl-2/Bax signal pathway.

Mar Drugs. 2015-3-12

[4]
Immunomodulatory Effects of -Acetyl Chitooligosaccharides on RAW264.7 Macrophages.

Mar Drugs. 2020-8-12

[5]
The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide.

Carbohydr Polym. 2017-7-19

[6]
Chitooligosaccharides Derivatives Protect ARPE-19 Cells against Acrolein-Induced Oxidative Injury.

Mar Drugs. 2023-2-22

[7]
Anticancer and anti-inflammatory properties of chitin and chitosan oligosaccharides.

J Funct Biomater. 2015-1-14

[8]
The inhibition of TNF-alpha-induced E-selectin expression in endothelial cells via the JNK/NF-kappaB pathways by highly N-acetylated chitooligosaccharides.

Biomaterials. 2007-3

[9]
Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model.

Carbohydr Polym. 2014-5-10

[10]
Chitosan oligosaccharides protect nucleus pulposus cells from hydrogen peroxide-induced apoptosis in a rat experimental model.

Biomed Pharmacother. 2017-7-14

本文引用的文献

[1]
Sulfated oligosaccharide activates endothelial Notch for inducing macrophage-associated arteriogenesis to treat ischemic diseases.

Proc Natl Acad Sci U S A. 2023-11-14

[2]
Anti-Obesity Effects of Chitosan and Its Derivatives.

Polymers (Basel). 2023-10-1

[3]
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging.

Arch Toxicol. 2023-10

[4]
Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway.

J Neuroinflammation. 2023-6-22

[5]
The neuroprotective effects of peracetylated chitosan oligosaccharides against β-amyloid-induced cognitive deficits in rats.

Mar Life Sci Technol. 2023-5-22

[6]
Activity of chitin/chitosan/chitosan oligosaccharide against plant pathogenic nematodes and potential modes of application in agriculture: A review.

Carbohydr Polym. 2023-4-15

[7]
The Role of Oxidative Stress in Atherosclerosis.

Cells. 2022-11-30

[8]
Chitosan oligosaccharide alleviates renal fibrosis through reducing oxidative stress damage and regulating TGF-β1/Smads pathway.

Sci Rep. 2022-11-10

[9]
The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia.

Int J Mol Sci. 2022-7-26

[10]
Chitosan oligosaccharides exert neuroprotective effects modulating the PI3K/Akt/Bcl-2 pathway in a Parkinsonian model.

Food Funct. 2022-5-23

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