α-羰基苄基溴、苯硫基氟代烷基溴和2-溴-2-苯氧基乙腈的亲核氟取代反应
Nucleophilic fluorine substitution reaction of α-carbonyl benzyl bromide, phenylthiofluoroalkyl bromide, and 2-bromo-2-phenoxyacetonitrile.
作者信息
Mizuta Satoshi, Yamaguchi Tomoko, Ishikawa Takeshi
机构信息
Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University 1-14 Bunkyo Nagasaki 852-8521 Japan.
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University 1-21-40 Korimoto Kagoshima 890-0065 Japan.
出版信息
RSC Adv. 2024 Jun 13;14(27):19062-19066. doi: 10.1039/d4ra03085k. eCollection 2024 Jun 12.
We herein describe a new method for nucleophilic fluorine substitution of alkylbromides using EtN·3HF. The process is characterized by a broad substrate scope, good functional-group compatibility, and mild conditions and provides a variety of alkylfluorides including tertiary alkylfluorides that are versatile and structurally attractive.
我们在此描述了一种使用EtN·3HF对烷基溴进行亲核氟取代的新方法。该过程的特点是底物范围广、官能团兼容性好、条件温和，并能提供多种烷基氟化物，包括具有通用性和结构吸引力的叔烷基氟化物。
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