Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Genesis. 2024 Jun;62(3):e23610. doi: 10.1002/dvg.23610.
The organization of the olfactory glomerular map involves the convergence of olfactory sensory neurons (OSNs) expressing the same odorant receptor (OR) into glomeruli in the olfactory bulb (OB). A remarkable feature of the olfactory glomerular map formation is that the identity of OR instructs the topography of the bulb, resulting in thousands of discrete glomeruli in mice. Several lines of evidence indicate that ORs control the expression levels of various kinds of transmembrane proteins to form glomeruli at appropriate regions of the OB. In this review, we will discuss how the OR identity is decoded by OSNs into gene expression through intracellular regulatory mechanisms.
嗅觉小球图的组织涉及表达相同气味受体 (OR) 的嗅觉感觉神经元 (OSN) 汇聚到嗅球 (OB) 中的小球中。嗅觉小球图形成的一个显著特征是 OR 决定了小球的拓扑结构,导致在小鼠中形成数千个离散的小球。有几条证据表明,OR 控制着各种跨膜蛋白的表达水平,从而在 OB 的适当区域形成小球。在这篇综述中,我们将讨论 OR 身份如何通过细胞内调节机制被 OSN 解码为基因表达。