Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Neurosci Res. 2021 Sep;170:1-5. doi: 10.1016/j.neures.2020.06.007. Epub 2020 Jul 1.
The development of precise neural circuits is initially directed by genetic programming and subsequently refined by neural activity. In the mouse olfactory system, axons from various olfactory sensory neurons expressing the same olfactory receptor converge onto a few spatially invariant glomeruli, generating the olfactory glomerular map in the olfactory bulbs. Using the glomerular map formation as a model, this review summarizes the current understanding of mechanisms underlying topographic map development in the mouse olfactory system and highlights how neural activity instructs the map refinement process.
精确的神经回路的发育最初由遗传编程指导，随后由神经活动进行精细调整。在小鼠嗅觉系统中，表达相同嗅觉受体的各种嗅觉感觉神经元的轴突汇聚到少数几个空间不变的神经球上，从而在嗅球中产生嗅觉神经球图。本文以神经球图的形成为模型，总结了目前对于小鼠嗅觉系统中拓扑图发育机制的理解，并强调了神经活动如何指导图谱的精细化过程。
