Lesch O M, Dietzel-Rogan M, Musalek M, Rajna P, Rustembegovich A, Schjerve M, Walter H
Psychiatr Prax. 1985 Mar;12(2):63-8.
All long-term patients with the diagnosis "paraphrenia systematica" out of one region were included in this study. 53 patients were treated in an in-patient psychiatric unit between 1979 and 1981 and were available in this study. Parenteral Fluphenacin-Decanoate (25-75 mg monthly) was given. Before, during and after Fluphenacin (each schedule lasting for at least 20 weeks) psychopathological and social evaluations were done. We used quantitative scales: NGI (Nurses Global Impressions) and BPRS (Brief psychiatric Rating Scale). Good Socialization showed a striking correlation to parenteral Fluphenacin-treatment. Differences in the present state psychopathology were not able to explain the social difference. During parenteral treatment 49 patients switched from badly socialized (NGI: more than 12 points) to well socialized (NGI less than 7 points). 18 patients stopped parenteral neuroleptic treatment for various reasons. 13 Patients out of this group had to be readmitted to the psychiatric hospital, while those staying on their parenteral neuroleptic drug-treatment stayed well socialized.
该研究纳入了来自同一地区所有诊断为“系统性类偏执狂”的长期患者。1979年至1981年间,有53名患者在住院精神科接受治疗,本研究可获取这些患者的数据。给予长效氟奋乃静癸酸酯(每月25 - 75毫克)。在使用氟奋乃静之前、期间和之后(每个阶段至少持续20周),进行了精神病理学和社会评估。我们使用了定量量表:护士总体印象量表(NGI)和简明精神病评定量表(BPRS)。良好的社交化与长效氟奋乃静治疗显著相关。当前精神病理学状态的差异无法解释社交方面的差异。在长效治疗期间,49名患者从社交不良(NGI:超过12分)转变为社交良好(NGI低于7分)。18名患者因各种原因停止了长效抗精神病药物治疗。该组中有13名患者不得不再次入住精神病院,而继续接受长效抗精神病药物治疗的患者保持了良好的社交化状态。