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维拉帕米可诱导清醒的非糖尿病大鼠出现葡萄糖不耐受。

Verapamil induces glucose intolerance in conscious, nondiabetic rats.

作者信息

Eng L A, Lee J C

出版信息

Res Commun Chem Pathol Pharmacol. 1985 Apr;48(1):157-60.

PMID:3887529
Abstract

Intravenous verapamil administration in normal rats significantly impaired the rats' ability to respond to a glucose tolerance test, and blocked the glucose-stimulated release of insulin into the blood. The results suggest that verapamil can impair pancreatic endocrine function in vivo.

摘要

对正常大鼠静脉注射维拉帕米会显著损害其对葡萄糖耐量试验的反应能力,并阻断葡萄糖刺激的胰岛素释放进入血液。结果表明,维拉帕米在体内可损害胰腺内分泌功能。

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