Krueger T C, Tallent M B, Richie R E, Johnson H K, MacDonell R C, Turner B
South Med J. 1985 May;78(5):501-6. doi: 10.1097/00007611-198505000-00002.
This review examines a 20-year experience in renal transplantation at our center to determine the effects of immunosuppression on the subsequent development of malignancies. Twenty patients had 21 malignancies from primary sites other than skin, yielding an incidence of 2.5%. There were 0.65 malignancies for each 100 cumulative patient years of immunosuppression. Suppression of the host immune response is associated with an increased incidence of malignancies.
本综述研究了我们中心20年的肾移植经验，以确定免疫抑制对后续恶性肿瘤发生的影响。20例患者发生了21例非皮肤原发部位的恶性肿瘤，发病率为2.5%。每100个免疫抑制累积患者年中有0.65例恶性肿瘤。宿主免疫反应的抑制与恶性肿瘤发病率的增加有关。
