Clinical Laboratory Center, First Affiliated Hospital of Guilin Medical University, 109 Ring City North Second Road, Guilin, 541004, Guangxi, China.
Guangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Sci Rep. 2024 Jun 14;14(1):13752. doi: 10.1038/s41598-024-64557-9.
OPFRs are emerging environmental pollutants with reproductive and endocrine toxicity. This study aimed to examine the association between environmental exposure to OPFRs during early pregnancy and GDM. This nested case-control study was based on a birth cohort that was constructed at a maternal and child health hospital, including 74 cases of GDM among 512 pregnant women. The OPFRs, including TBP, TBEP, TCEP, TDCPP, TMCP, TOCP, and TPHP during 10-14 weeks of pregnancy were determined using GC-MS. The association between the OPFRs and GDM was assessed using WQS and BKMR models. The levels of OPFRs were significantly elevated in GDM patients (60) compared with the controls (90). The WQS analysis showed that mixtures of the OPFRs were significantly associated with GDM (OR 1.370, 95% CI 1.036-1.810, P = 0.027), and TBP, TPHP, and TMCP were the major contributors to the mixed exposure effect. In the BKMR model, individual exposure to TBP, TPHP, and TMCP, and the interaction of TMCP with TBP and TPHP were significantly associated with GDM. Environmental exposure to OPFRs is positively associated with GDM. These findings provide evidence for the adverse effects of OPFR exposure on the health of pregnant women.
邻苯二甲酸酯是新兴的环境污染物，具有生殖毒性和内分泌干扰作用。本研究旨在探讨妊娠早期环境暴露于邻苯二甲酸酯与妊娠期糖尿病（GDM）之间的关系。这项嵌套病例对照研究基于一个在妇幼保健医院建立的队列研究，包括 512 名孕妇中的 74 例 GDM。在妊娠 10-14 周时，使用 GC-MS 测定 TBP、TBEP、TCEP、TDCPP、TMCP、TOCP 和 TPHP 等邻苯二甲酸酯。使用 WQS 和 BKMR 模型评估邻苯二甲酸酯与 GDM 的关联。GDM 患者（60 例）的邻苯二甲酸酯水平明显高于对照组（90 例）（P<0.001）。WQS 分析显示，邻苯二甲酸酯混合物与 GDM 显著相关（OR 1.370，95%CI 1.036-1.810，P=0.027），TBP、TPHP 和 TMCP 是混合暴露效应的主要贡献者。在 BKMR 模型中，TBP、TPHP 和 TMCP 的个体暴露以及 TMCP 与 TBP 和 TPHP 的相互作用与 GDM 显著相关。环境暴露于邻苯二甲酸酯与 GDM 呈正相关。这些发现为邻苯二甲酸酯暴露对孕妇健康的不良影响提供了证据。
