Bergström J, Ahlberg M, Alvestrand A
Acta Med Scand. 1985;217(2):189-96. doi: 10.1111/j.0954-6820.1985.tb01655.x.
Glomerular filtration rate (GFR) by clearance of inulin and creatinine and effective renal plasma flow (ERPF) by para-aminohippurate clearance was investigated in 8 normal volunteers on low protein (LP) and high protein (HP) diet for 6 days in the basal state and after a mixed protein-rich test meal. Plasma immunoreactive insulin (IRI), glucagon (IRG) and growth hormone (IRHGH) were followed before and after the test meal. GFR was higher on HP than on LP diet and increased within one hour after the test meal. ERPF also increased significantly after the meal on LP diet. IRI increased maximally at 60 min after the test meal and then declined gradually. IRG increased after a latency period of 90 min and IRHGH consistently did not change. Since the increase in GFR was significant already one hour after the test meal, i.e. before IRG was changed, we conclude that glucagon is not a mediator of the protein-induced increased in GFR. Neither insulin nor growth hormone appeared to be involved.
在8名正常志愿者中，研究了基础状态下以及富含蛋白质的混合试验餐前后，6天低蛋白（LP）和高蛋白（HP）饮食时菊粉清除率和肌酐清除率所测定的肾小球滤过率（GFR），以及对氨基马尿酸清除率所测定的有效肾血浆流量（ERPF）。测定了试验餐前后血浆免疫反应性胰岛素（IRI）、胰高血糖素（IRG）和生长激素（IRHGH）水平。HP饮食时的GFR高于LP饮食，且在试验餐后1小时内升高。LP饮食时餐后ERPF也显著增加。IRI在试验餐后60分钟达到最大增加，然后逐渐下降。IRG在90分钟的潜伏期后增加，而IRHGH一直没有变化。由于试验餐后1小时，即IRG改变之前，GFR的增加就很显著，因此我们得出结论，胰高血糖素不是蛋白质诱导的GFR增加的介质。胰岛素和生长激素似乎也未参与其中。
