Lichtig C, Deutsch M, Brandes J
Am J Clin Pathol. 1985 May;83(5):633-6. doi: 10.1093/ajcp/83.5.633.
Endometrial spiral arteries from curetted endometrium of 110 first-trimester pregnancies were studied by immunofluorescent (IF) technics using antibodies against human G, M, and A immunoglobulins, C3, C4, and fibrinogen. Heavy deposition of C3 in the arterial walls was found in 16 (14.6%) cases. Immunoglobulins, C4, and fibrinogen were found in only a few cases, and their staining was weak and not considered in this study. There was also a statistically significant (P less than 0.01) higher deposition of C3 in arterial walls of primipara (14 of 52), as compared to multipara (2 of 58). The possible mechanisms of C3 deposition and the importance of the higher incidence of this deposition in primipara are discussed in relation to suggested immunologic pathogenetic alterations in preeclampsia.
采用针对人G、M和A免疫球蛋白、C3、C4和纤维蛋白原的抗体，通过免疫荧光技术对110例早孕刮宫子宫内膜的螺旋动脉进行了研究。在16例（14.6%）病例中发现动脉壁有大量C3沉积。仅在少数病例中发现免疫球蛋白、C4和纤维蛋白原，且其染色较弱，本研究未予考虑。与经产妇（58例中的2例）相比，初产妇（52例中的14例）动脉壁中C3的沉积在统计学上也有显著更高（P小于0.01）。结合子痫前期免疫发病机制改变的相关提示，讨论了C3沉积的可能机制以及初产妇中这种沉积发生率较高的重要性。
