Tong Kuinan, Jing Chao, Wang Tingting, Liu Kun, Guo Wei, Zhang Zhongtao
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Asian J Surg. 2024 Jun 14. doi: 10.1016/j.asjsur.2024.05.243.
Gallstones (GSs) disease is a common disease worldwide. The mechanisms of their formation are diverse and complex and are related to cholesterol metabolism, gallbladder motility, biliary tract infection, the immune response, and ion metabolism. In recent years, with the application of inductively coupled plasma‒mass spectrometry and other methods, studies have suggested a correlation between the metabolism of metal ions and GSs formation. A literature search on gallstones and metal ions was instituted on PubMed and EMBASE. The specific topics of interest were etiology, formation mechanism, component Analysis and metabolism. References of papers were subsequently searched to obtain older literature. After reading and summarizing a large amount of literature, we found that calcium, iron, and copper can potentially promote the release of inflammatory factors and increase the level of reactive oxygen species, which is positively correlated with GSs formation. While magnesium and zinc, with their antioxidant effects, are negatively correlated with GSs formation. Metal ions are not only a component of GSs but are also important biological signals. Metal ion metabolism affects the formation of GSs and understanding its mechanism of action is of clinical significance for the prevention, diagnosis and treatment of GSs.
胆结石（GSs）疾病是一种全球范围内的常见疾病。其形成机制多样且复杂，与胆固醇代谢、胆囊运动、胆道感染、免疫反应及离子代谢有关。近年来，随着电感耦合等离子体质谱等方法的应用，研究表明金属离子代谢与GSs形成之间存在关联。我们在PubMed和EMBASE上对胆结石与金属离子进行了文献检索。感兴趣的具体主题包括病因、形成机制、成分分析和代谢。随后对论文的参考文献进行检索以获取更早的文献。在阅读和总结大量文献后，我们发现钙、铁和铜可能会促进炎症因子的释放并增加活性氧水平，这与GSs形成呈正相关。而具有抗氧化作用的镁和锌与GSs形成呈负相关。金属离子不仅是GSs的组成成分，也是重要的生物信号。金属离子代谢影响GSs的形成，了解其作用机制对GSs的预防、诊断和治疗具有临床意义。
