Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.
College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Mini Rev Med Chem. 2024;24(22):2008-2018. doi: 10.2174/0113895575293544240605112838.
CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3'UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.
A total of 95 articles were eligible for inclusion based on the year, quality of the research, and the strength of association with CPEB1. In this review, current research about how CPEB1 affects the initiation and progression of glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma are dissected, and the biomedical functions and mechanisms are summarized.
CPEB1 mostly presents as a tumor suppressor for breast cancer, endometrial carcinoma, hepatocellular carcinoma, non-small cell lung cancer, prostate cancer, and melanoma. However, for glioblastoma, gastric cancer, and colorectal cancer, CPEB1 exhibts two opposing properties of tumorigenesis, either promoting or inhibiting it.
CPEB1 is likely to serve as a target and dynamic detection index or prognostic indicator for its function of apoptosis, activity, proliferation, migration, invasion, stemness, drug resistance, and even ferroptosis in various cancers.
CPEB1 是一种另类聚腺苷酸化结合蛋白，通过与 mRNA 3'UTR 中的高度保守的细胞质聚腺苷酸化元件（CPE）结合，促进或抑制相关 mRNA 和蛋白质的表达。它在多种肿瘤中异常表达，并通过多种途径影响肿瘤发生。本综述总结了 CPEB1 在多种癌症中的功能和机制，并为未来相关治疗提出了新的方向。
根据研究年份、研究质量和与 CPEB1 关联的强度，共纳入 95 篇符合条件的文章。在本综述中，我们剖析了 CPEB1 如何影响脑胶质瘤、乳腺癌、肝癌、胃癌、结直肠癌、非小细胞肺癌、前列腺癌和黑色素瘤的发生和发展，并总结了其生物医学功能和机制。
CPEB1 主要作为乳腺癌、子宫内膜癌、肝癌、非小细胞肺癌、前列腺癌和黑色素瘤的肿瘤抑制因子发挥作用。然而，对于脑胶质瘤、胃癌和结直肠癌，CPEB1 表现出两种相反的促癌特性。
CPEB1 可能作为各种癌症中凋亡、活性、增殖、迁移、侵袭、干性、耐药性甚至铁死亡等功能的靶点和动态检测指标或预后标志物。
