Key Laboratory of Materials Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Materials Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, State Key Laboratory of Materials Processing and Die & Mould Technology, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
Key Laboratory of Human-Machine-Intelligence Synergic System, Research Center for Neural Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Macromol Rapid Commun. 2024 Oct;45(20):e2400371. doi: 10.1002/marc.202400371. Epub 2024 Jun 25.
Diversity in solvent selection bestows the organic gel with appealing characteristics embracing antidrying, anti-icing, and antifouling abilities. However, organic gel, subjected to the "toxic" inherent property of solvent, is not able to be manipulated on skin. Herein, introducing the hydrogel layer amid organic gel and skin is envisaged to realize application of organic gel on skin. Hydrogel, inserted as the medium layer, works for the coupling role between skin and organic gel, also avoids the direct contact of organic gel toward skin. First, hydrogel system composed of acrylic acid is fabricated, meanwhile organic gel is prepared employing 2-hydroxyethyl methacrylate, ethylene glycol (EG) as solvent. Organic gel is able to adhere to hydrogel by hydrogen bonding resulting from carboxyl groups of polyacrylic acid chains and hydroxyl groups occurring on 2-hydroxyethyl methacrylate or EG. Additionally, hydrogen bonding enables the hydrogel to be firmly attached to skin, thus organic gel/hydrogel/skin assembly is produced. The further application of organic gel is exploited by incorporating stimuli-responsive dyes including spiropyran and rhodamine derivative.
溶剂选择的多样性赋予有机凝胶吸引人的特性，包括抗干燥、抗结冰和防污能力。然而，由于溶剂固有的“毒性”，有机凝胶不能在皮肤上操作。在此，设想在有机凝胶和皮肤之间引入水凝胶层，以实现有机凝胶在皮肤上的应用。水凝胶作为中间层插入，在皮肤和有机凝胶之间起到偶联作用，同时避免有机凝胶与皮肤直接接触。首先，制备了由丙烯酸组成的水凝胶体系，同时采用 2-羟乙基甲基丙烯酸酯和乙二醇（EG）作为溶剂制备有机凝胶。有机凝胶通过聚丙烯酸链上的羧基基团和 2-羟乙基甲基丙烯酸酯或 EG 上的羟基基团之间的氢键与水凝胶结合。此外，氢键使水凝胶能够牢固地附着在皮肤上，从而制备出有机凝胶/水凝胶/皮肤的组装体。通过掺入对刺激响应的染料，包括螺吡喃和罗丹明衍生物，进一步开发了有机凝胶的应用。
