Li Xi, Ye Chunshui, Wang Min, Kwan Patrick, Tian Xin, Zhang Yanke
Jining Medical University, Jining, 272000, China.
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, 272000, China.
Neurosci Bull. 2025 Jan;41(1):93-106. doi: 10.1007/s12264-024-01238-7. Epub 2024 Jun 16.
The nervous system is the dominant regulatory system in the human body. The traditional theory is that tumors lack innervation. However, an increasing number of studies have shown complex bidirectional interactions between tumors and the nervous system. Globally, colorectal cancer (CRC) is the third most common cancer. With the rise of tumor neuroscience, the role of nervous system imbalances in the occurrence and development of CRC has attracted increasing amounts of attention. However, there are still many gaps in the research on the interactions and mechanisms involved in the nervous system in CRC. This article systematically reviews emerging research on the bidirectional relationships between the nervous system and CRC, focusing on the following areas: (1) Effects of the nervous system on colon cancer. (2) Effects of CRC on the nervous system. (3) Treatment of CRC associated with the nervous system.
神经系统是人体主要的调节系统。传统理论认为肿瘤缺乏神经支配。然而，越来越多的研究表明肿瘤与神经系统之间存在复杂的双向相互作用。在全球范围内，结直肠癌（CRC）是第三大常见癌症。随着肿瘤神经科学的兴起，神经系统失衡在CRC发生发展中的作用已引起越来越多的关注。然而，关于CRC中神经系统相互作用及其机制的研究仍存在许多空白。本文系统综述了神经系统与CRC之间双向关系的新兴研究，重点关注以下几个方面：（1）神经系统对结肠癌的影响。（2）CRC对神经系统的影响。（3）与神经系统相关的CRC治疗。
