Silva-Júnior Edeildo Ferreira da
Research Group of Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Lourival Melo Mota Avenue, AC. Simões Campus, 57072-970 Alagoas, Maceió, Brazil.
Bioorg Med Chem. 2024 Jul 15;109:117797. doi: 10.1016/j.bmc.2024.117797. Epub 2024 Jun 9.
This perspective underscores the rising challenge posed by emerging diseases against the backdrop of modern advancements in global public health understanding. It particularly highlights the emergence of the Oropouche virus (OROV) as a significant global threat, detailing its transmission dynamics, symptoms, and epidemiological impact, with a focus on its historical and current manifestations. It further delves into the molecular aspects of OROV, elucidating its unique characteristics, lack of structural similarity with other arboviruses, and the limited progress in medicinal chemistry research. Still, it highlights notable studies on potential antiviral agents and the challenges in drug development, emphasizing the need for innovative approaches such as structure-based drug design (SBDD) and drug repurposing. Finally, it concludes with a call to action, urging increased attention and research focus on OROV to prevent potential future pandemics fueled by viral mutations.
这一观点强调了在全球公共卫生认知取得现代进展的背景下，新兴疾病带来的日益严峻的挑战。它特别突出了奥罗普切病毒（OROV）作为重大全球威胁的出现，详细阐述了其传播动态、症状和流行病学影响，重点关注其历史和当前表现。它进一步深入研究了OROV的分子层面，阐明了其独特特征、与其他虫媒病毒缺乏结构相似性以及药物化学研究进展有限。尽管如此，它突出了关于潜在抗病毒药物的显著研究以及药物开发中的挑战，强调了基于结构的药物设计（SBDD）和药物重新利用等创新方法的必要性。最后，它发出行动呼吁，敦促加大对OROV的关注和研究力度，以预防未来可能因病毒突变引发的大流行。
