Department of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Osteoarthritis Cartilage. 2024 Sep;32(9):1163-1171. doi: 10.1016/j.joca.2024.06.005. Epub 2024 Jun 14.
To examine associations of vibration sensitivity and pressure pain sensitivity with knee osteoarthritis (OA) outcomes across sex and race, which may relate to known sex and race disparities in clinical outcomes.
Data were from the 2013-2015 visit of the Johnston County Osteoarthritis Project. Exposures were vibration perception threshold (VPT) measured at the bilateral medial femoral condyle (MFC) and first metatarsophalangeal joint (MTP), and pressure pain threshold (PPT) measured at the bilateral upper trapezius. Outcomes were knee pain severity and presence of knee symptoms, radiographic knee OA, and symptomatic knee OA in each knee. Cross-sectional associations of the exposures with the outcomes were examined using logistic regression models, overall and separately by sex and race.
In the VPT and PPT analyses, 851 and 862 participants (mean age 71 years, 68% female, 33% Black, body mass index 31 kg/m) and 1585 and 1660 knees were included, respectively. Higher VPT (lower vibration sensitivity) at the MFC and first MTP joint was associated with all outcomes. Lower PPT (greater pressure pain sensitivity) was associated with greater knee pain severity. Associations of VPT and PPT with all outcomes were similar among females and males and Black and White individuals.
Diminished vibration perception and greater pressure pain sensitivity were cross-sectionally associated with worse knee OA outcomes. Despite differences in VPT and PPT among females and males and Black and White adults, associations with knee OA outcomes did not differ by sex or race, suggesting neurophysiological differences do not relate to established disparities.
研究振动感知敏感性和压痛感知敏感性与膝关节骨关节炎（OA）结局的相关性，这些相关性可能与性别和种族相关的已知临床结局差异有关。
数据来自 2013-2015 年约翰斯顿县骨关节炎项目的访问。暴露因素为双侧股骨内侧髁（MFC）和第一跖趾关节（MTP）的振动感知阈值（VPT）测量值，以及双侧上斜方肌的压痛感知阈值（PPT）测量值。结局为膝关节疼痛严重程度和膝关节症状的存在、膝关节放射照相 OA 和每个膝关节的症状性膝关节 OA。使用逻辑回归模型，总体上和分别按性别和种族检查了暴露因素与结局的交叉关联。
在 VPT 和 PPT 分析中，分别纳入了 851 名和 862 名参与者（平均年龄 71 岁，68%为女性，33%为黑人，体重指数 31kg/m）和 1585 名和 1660 名膝关节。MFC 和第一 MTP 关节的 VPT 较高（振动感知敏感性较低）与所有结局均相关。较低的 PPT（更大的压痛感知敏感性）与更大的膝关节疼痛严重程度相关。女性和男性以及黑人和白人个体中，VPT 和 PPT 与所有结局的关联相似。
振动感知减退和压痛感知敏感性增加与膝关节 OA 结局较差呈横断面相关。尽管女性和男性以及黑人和白人成年人之间的 VPT 和 PPT 存在差异，但与膝关节 OA 结局的关联并无性别或种族差异，这表明神经生理学差异与已确立的差异无关。
