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全氟化合物乳剂氧输送液:临床综述

Perfluorochemical emulsion oxygen transport fluids: a clinical review.

作者信息

Tremper K K, Anderson S T

出版信息

Annu Rev Med. 1985;36:309-13. doi: 10.1146/annurev.me.36.020185.001521.

DOI:10.1146/annurev.me.36.020185.001521
PMID:3888055
Abstract

Perfluorochemical liquids are inert, immiscible in water, and have approximately 20 times the solubility for oxygen and carbon dioxide as does water. When emulsified in a normal saline solution, they can act as an oxygen-transporting resuscitation fluid. Fluosol-DA 20% is the first perfluorochemical emulsion to be studied clinically. It can supplement oxygen transport in anemic patients, but no control study has as yet determined its clinical effectiveness.

摘要

全氟化合物液体呈惰性,与水不混溶,其氧气和二氧化碳的溶解度约为水的20倍。当在生理盐水溶液中乳化时,它们可作为一种输氧复苏液。氟碳乳剂-DA 20%是首个进行临床研究的全氟化合物乳剂。它可补充贫血患者的氧输送,但尚无对照研究确定其临床疗效。

相似文献

1
Perfluorochemical emulsion oxygen transport fluids: a clinical review.全氟化合物乳剂氧输送液:临床综述
Annu Rev Med. 1985;36:309-13. doi: 10.1146/annurev.me.36.020185.001521.
2
The preoperative treatment of severely anemic patients with a perfluorochemical oxygen-transport fluid, Fluosol-DA.
N Engl J Med. 1982 Jul 29;307(5):277-83. doi: 10.1056/NEJM198207293070503.
3
Rationale for the clinical studies of anemia treated with the perfluorochemical emulsion: Fluosol DA 20%.
Prog Clin Biol Res. 1983;122:307-13.
4
Clinical experience with Fluosol-DA (20%) in the United States.美国氟碳乳剂(20%)的临床经验。
Int Anesthesiol Clin. 1985 Spring;23(1):185-97. doi: 10.1097/00004311-198502310-00017.
5
Initial Canadian experience with artificial blood (Fluosol-DA-20%) in severely anemic patients.加拿大在严重贫血患者中使用人造血液(氟碳代血液-DA-20%)的初步经验。
J Cardiovasc Surg (Torino). 1985 Jul-Aug;26(4):337-42.
6
Hemodynamic and oxygen transport effects of a perfluorochemical blood substitute, fluosol-DA (20%).全氟化学血液代用品氟碳乳剂(20%)的血液动力学及氧运输效应
Crit Care Med. 1980 Dec;8(12):738-41. doi: 10.1097/00003246-198012000-00009.
7
Development of a perfluorochemical whole blood substitute (Fluosol-DA, 20%)--an overview of clinical studies with 185 patients.
Prog Clin Biol Res. 1981;55:609-28.
8
Development and clinical application of perfluorochemical artificial blood.全氟化合物人造血液的研制与临床应用
Int J Artif Organs. 1986 Sep;9(5):363-8.
9
Fluosol DA-20% in treatment of severe anemia: ongoing studies in 52 patients.氟碳代血液DA-20%治疗严重贫血:52例患者的正在进行的研究。
Biomater Artif Cells Immobilization Biotechnol. 1992;20(2-4):1069. doi: 10.3109/10731199209119765.
10
Which is the foreseeable clinical application of oxygen-carrying blood substitutes (fluorocarbons and hemoglobin solutions)? Which impact are they likely to have on the activity of blood services?携氧血液替代品(氟碳化合物和血红蛋白溶液)可预见的临床应用是什么?它们可能会对血液服务活动产生哪些影响?
Vox Sang. 1982 Feb;42(2):97-109. doi: 10.1159/000460856.

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