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MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma.

作者信息

Song Haimin, Ni Bowen, Peng Xuetao, Xu Weijuan, Yang Shaochun, Yang Runwei, Wang Ziyu, Li Kaishu, Lin Rui, Zhang Yunxiao, Guo Jinglin, Wu Kezhi, Shi Guangwei, Sun Jichao, He Chunming, Liu Yawei

机构信息

Department of Neurosurgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China.

Department of Neurosurgery & Medical Research Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, Guangdong 528300, China.

出版信息

Genes Dis. 2023 Sep 9;11(5):101085. doi: 10.1016/j.gendis.2023.101085. eCollection 2024 Sep.

DOI:10.1016/j.gendis.2023.101085
PMID:38882007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11176650/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/df006aa099db/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/867cb822e55f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/d2a775c4316d/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/f8b7c4a19269/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/43711949a776/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/a3a88716c6f1/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/f452672f845c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/df006aa099db/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/867cb822e55f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/d2a775c4316d/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/f8b7c4a19269/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/43711949a776/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/a3a88716c6f1/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/f452672f845c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6802/11176650/df006aa099db/figs6.jpg

相似文献

[1]
MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma.

Genes Dis. 2023-9-9

[2]
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Biomed Res Int. 2019-2-11

[3]
MPZL1 Promotes Lung Adenocarcinoma Progression by Enhancing Tumor Proliferation, Invasion, Migration, and Suppressing Immune Function via Transforming Growth Factor-β1.

Hum Gene Ther. 2023-6

[4]
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Oncol Rep. 2019-6-12

[5]
HGF-induced formation of the MET-AXL-ELMO2-DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion.

J Biol Chem. 2018-8-14

[6]
MPZL1 suppresses the cancer stem-like properties of lung cancer through β-catenin/TCF4 signaling.

Funct Integr Genomics. 2023-9-19

[7]
Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy.

Mol Cancer Ther. 2009-2

[8]
Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor.

Ann Surg. 2005-5

[9]
LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome.

Int J Biol Sci. 2022

[10]
MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells.

Mol Med Rep. 2019-7-18

引用本文的文献

[1]
Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma.

Respir Res. 2025-4-13

本文引用的文献

[1]
Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition.

EBioMedicine. 2022-12

[2]
Identification of genomic and molecular traits that present therapeutic vulnerability to HGF-targeted therapy in glioblastoma.

Neuro Oncol. 2019-2-14

[3]
Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy.

Neuro Oncol. 2018-1-22

[4]
Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Onartuzumab Plus Bevacizumab Versus Placebo Plus Bevacizumab in Patients With Recurrent Glioblastoma: Efficacy, Safety, and Hepatocyte Growth Factor and O-Methylguanine-DNA Methyltransferase Biomarker Analyses.

J Clin Oncol. 2016-12-5

[5]
The Phyre2 web portal for protein modeling, prediction and analysis.

Nat Protoc. 2015-6

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