血浆Aβ1-40对阿尔茨海默病的预后价值。

Prognostic value of plasma Aβ1-40 for Alzheimer's disease.

作者信息

Lv Hui, Tang Lingjiao, Jian Chongdong, Wei Anshang, Li Dengxing, Jiang Yongming, Yang Chengmin, Mo Shenglong, Shang Jingwei, Li Xinzhou

机构信息

Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities Baise 533000, Guangxi, China.

College of Nursing of Youjiang Medical University for Nationalities Baise 533000, Guangxi, China.

出版信息

Am J Transl Res. 2024 May 15;16(5):1962-1968. doi: 10.62347/PIYV4216. eCollection 2024.

DOI:10.62347/PIYV4216

PMID:38883359

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11170593/

Abstract

OBJECTIVE

To investigate the clinical significance of plasma p-amyloid 1-40 (Aβ1-40) in patients with Alzheimer's disease (AD).

METHODS

In this retrospective study, the clinical data of 305 patients, with or without Alzheimer's disease (AD), who were treated at the Affiliated Hospital of Youjiang Medical University for Nationalities and the People's Hospital of Baise between January 2018 and December 2021 were analyzed. Patients were divided into two groups: an AD group (n=147) and a non-AD group (without AD, n=158 cases). Blood test indices, including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (CRE), high-sensitivity C-reactive protein (hsCRP), and plasma β-amyloid 1-40 were collected and compared between the two groups.

RESULTS

The plasma β-amyloid 1-40 in the AD group was (3.71±3.45) mol/L, which was significantly higher than (2.8±1.35) mmol/L in the non-AD group (P<0.05). Similarly, hsCRP expression was significantly higher in the AD group than that in the non-AD group (P<0.05). There were no significant differences in AST, ALT, UA, T-tau, NFL or Cr levels between the two groups (all P>0.05). Moreover, univariate regression analysis showed that plasma β-amyloid 1-40 and hsCRP were significantly correlated with AD. Multiple regression analysis demonstrated that plasma p-amyloid 1-40 (P<0.0001) and hsCRP (P=0.002) were independent predictors of AD.

CONCLUSION

Plasma p-amyloid 1-40 and hsCRP are closely related to AD, and may serve as important clinical predictors of AD.

摘要

目的

探讨血浆β淀粉样蛋白1-40（Aβ1-40）在阿尔茨海默病（AD）患者中的临床意义。

方法

本回顾性研究分析了2018年1月至2021年12月在右江民族医学院附属医院和百色市人民医院接受治疗的305例有无阿尔茨海默病（AD）患者的临床资料。患者分为两组：AD组（n = 147）和非AD组（无AD，n = 158例）。收集两组的血液检测指标，包括血清天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、肌酐（CRE）、高敏C反应蛋白（hsCRP）和血浆β淀粉样蛋白1-40，并进行比较。

结果

AD组血浆β淀粉样蛋白1-40为（3.71±3.45）mol/L，显著高于非AD组的（2.8±1.35）mmol/L（P<0.05）。同样，AD组hsCRP表达显著高于非AD组（P<0.05）。两组间AST、ALT、尿酸（UA）、总tau蛋白（T-tau）、神经丝轻链（NFL）或肌酐水平无显著差异（均P>0.05）。此外，单因素回归分析显示血浆β淀粉样蛋白1-40和hsCRP与AD显著相关。多因素回归分析表明血浆β淀粉样蛋白1-40（P<0.0001）和hsCRP（P = 0.002）是AD的独立预测因子。