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难治性心房扑动:新冠病毒感染新生儿的罕见表现——一例病例报告及文献综述

Refractory Atrial Flutter, the Unusual Presentation of Covid-19 Infection in a Neonate: A Case Report and Review of Literature.

作者信息

Saadat Seyed Hossein, Tariverdi Marjan, Kargarfard Jahromi Mohammadreza, Sharma Deepak, Farahbakhsh Nazanin

机构信息

Faculty of Medicine, Clinical Research Development Center of children's Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, IraC.

Assistant Professor of Pediatric Infectious Disease Department of Pediatrics, School of Medicine Hormozgan University of Medical Sciences.

出版信息

ARYA Atheroscler. 2023 Nov-Dec;19(6):44-48. doi: 10.48305/arya.2023.41673.2901.

Abstract

INTRODUCTION

The accurate incidence of different cardiovascular consequences of COVID-19 in the pediatric population has been inadequately defined due to ongoing genotype changes in the virus. Although COVID-19 is known to increase inflammatory markers associated with atrial arrhythmias, the contemporary literature has poorly described new onset arrhythmias as a complication in previously healthy neonates with COVID-19.

CASE PRESENTATION

A twenty-day-old female term neonate, born by caesarean section with immediate cry, developed labored breathing, cyanosis, and tachycardia after having close contact with a confirmed case of COVID-19. The neonate developed atrial flutter, which was refractory to cardioversion and drugs, namely Amiodarone, Flecainide, and Propranolol. The authors treated the neonate with IVIG. This is the first reported case of atrial flutter in the neonatal period secondary to COVID-19.

CONCLUSION

Since the start of the SARS-CoV-2 pandemic, all attention and concerns have been mainly on respiratory manifestations and complications. The cardiovascular complications and treatment have been neglected. This case reports tachyarrhythmia (Atrial Flutter) as an unusual presentation of acute COVID-19 in the neonatal population and shows the role of IVIG in the treatment of refractory arrhythmias.

摘要

引言

由于新冠病毒不断发生基因变化,儿童群体中新冠病毒感染引发的不同心血管后果的准确发病率尚未明确界定。尽管已知新冠病毒会增加与房性心律失常相关的炎症标志物,但当代文献对新冠病毒感染的健康新生儿出现新发心律失常这一并发症的描述甚少。

病例报告

一名20日龄足月女婴,剖宫产出生后哭声正常,在与一名确诊新冠病例密切接触后出现呼吸急促、发绀和心动过速。该新生儿发展为心房扑动,对心脏复律和药物(即胺碘酮、氟卡尼和普萘洛尔)均无反应。作者用静脉注射免疫球蛋白对该新生儿进行治疗。这是首例报告的新生儿期继发于新冠病毒感染的心房扑动病例。

结论

自新冠疫情开始以来,所有关注和担忧主要集中在呼吸道表现和并发症上。心血管并发症及治疗一直被忽视。本病例报告了快速性心律失常(心房扑动)作为新生儿群体急性新冠病毒感染的一种不寻常表现,并展示了静脉注射免疫球蛋白在治疗难治性心律失常中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a412/11178988/671a38a31617/ARYA-19-44-g001.jpg

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