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妊娠期高血压疾病与血管功能障碍

Hypertensive disorders of pregnancy & vascular dysfunction.

作者信息

Palatnik Anna, Kulinski Jacquelyn

机构信息

Division of Maternal Fetal Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.

Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.

出版信息

Front Cardiovasc Med. 2024 May 30;11:1411424. doi: 10.3389/fcvm.2024.1411424. eCollection 2024.

Abstract

Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and fetal morbidity and mortality. One of the more severe HDP diagnoses is preeclampsia, which is recognized as a sex-specific cardiovascular risk enhancer with long-term implications for women's health, increasing lifetime risk of ischemic heart disease, stroke, and heart failure. Though the mechanisms accounting for the increased risk of cardiovascular disease following HDP are not yet well understood, vascular dysfunction has been implicated. In this perspective piece, we summarize the existing evidence for vascular dysfunction in HDP with a focus on non-invasive assessments, highlight advances in the field, and suggest future directions for improving risk stratification of women with HDP.

摘要

妊娠高血压疾病(HDP)是孕产妇和胎儿发病及死亡的主要原因。子痫前期是更严重的HDP诊断之一,它被认为是一种性别特异性的心血管风险增强因素,对女性健康有长期影响,会增加缺血性心脏病、中风和心力衰竭的终生风险。尽管HDP后心血管疾病风险增加的机制尚未完全明确,但血管功能障碍与之有关。在这篇观点文章中,我们总结了HDP中血管功能障碍的现有证据,重点关注非侵入性评估,突出该领域的进展,并提出改善HDP女性风险分层的未来方向。

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