Oguntade Babatunde Opeyemi, Ibitoye Bolanle Olubunmi, Makinde Olufemiwa Niyi, Idowu Bukunmi Michael, Okedere Tolulope Adebayo
Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria.
Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria.
J Med Ultrasound. 2023 Oct 6;32(1):48-54. doi: 10.4103/jmu.jmu_10_23. eCollection 2024 Jan-Mar.
Hypertensive disorder of pregnancy (HDP) comprise chronic hypertension, gestational hypertension, preeclampsia/eclampsia, and preeclampsia superimposed on chronic hypertension. HDP complicate up to 10% of pregnancies worldwide and carry significant risks of maternal and perinatal morbidity and mortality. The aim of this study was to evaluate the derangement and characteristics of brachial artery flow-mediated dilation (BAFMD) in women with HDP.
The BAFMD of the right brachial artery of 80 women with HDP (pregnant HDP), 80 normotensive pregnant women (pregnant non-HDP), and 80 healthy nonpregnant women (nonpregnant controls) was evaluated with B-mode ultrasound. The age, blood pressure, body mass index (BMI), brachial artery diameter, and BAFMD of the participants were compared. ≤ 0.05 was statistically significant.
The pregnant HDP group had significantly lower mean BAFMD compared to pregnant non-HDP and nonpregnant controls (6.9% ± 2.53% vs. 8.32% ± 3.4% vs. 9.4% ± 2.68%; < 0.001). There was no significant difference between the mean BAFMD of the pregnant HDP subgroups: preeclampsia (5.81% ± 1.7%) versus gestational hypertension (6.43% ± 3.02%); = 0.57. BAFMD diminished with advancing gestational age in both the pregnant HDP and pregnant non-HDP groups. On regression analysis, BAFMD was a poor marker for HDP, while BMI was an independent predictor for HDP.
Even though HDP were associated with significantly diminished BAFMD, it was not a good marker for HDP.
妊娠期高血压疾病（HDP）包括慢性高血压、妊娠期高血压、子痫前期/子痫，以及慢性高血压并发子痫前期。HDP在全球高达10%的妊娠中出现并发症，并带来孕产妇和围产期发病及死亡的重大风险。本研究的目的是评估HDP女性肱动脉血流介导的血管舒张功能（BAFMD）的紊乱情况和特征。
采用B型超声评估80例HDP孕妇（妊娠HDP组）、80例血压正常的孕妇（非妊娠HDP组）和80例健康非妊娠女性（非妊娠对照组）右侧肱动脉的BAFMD。比较参与者的年龄、血压、体重指数（BMI）、肱动脉直径和BAFMD。P≤0.05具有统计学意义。
与非妊娠HDP组和非妊娠对照组相比，妊娠HDP组的平均BAFMD显著降低（6.9%±2.53% vs. 8.32%±3.4% vs. 9.4%±2.68%；P<0.001）。妊娠HDP亚组之间的平均BAFMD无显著差异：子痫前期（5.81%±1.7%）与妊娠期高血压（6.43%±3.02%）；P=0.57。在妊娠HDP组和非妊娠HDP组中，BAFMD均随孕周增加而降低。回归分析显示，BAFMD不是HDP的良好标志物，而BMI是HDP的独立预测因素。
尽管HDP与BAFMD显著降低有关，但它不是HDP的良好标志物。
