妊娠期高血压疾病女性肱动脉的血流介导的扩张

Flow-mediated Dilation of the Brachial Artery in Women with Hypertensive Disorders of Pregnancy.

作者信息

Oguntade Babatunde Opeyemi, Ibitoye Bolanle Olubunmi, Makinde Olufemiwa Niyi, Idowu Bukunmi Michael, Okedere Tolulope Adebayo

机构信息

Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria.

Department of Obstetrics and Gynecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria.

出版信息

J Med Ultrasound. 2023 Oct 6;32(1):48-54. doi: 10.4103/jmu.jmu_10_23. eCollection 2024 Jan-Mar.

DOI:10.4103/jmu.jmu_10_23

PMID:38665342

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11040488/

Abstract

BACKGROUND

Hypertensive disorder of pregnancy (HDP) comprise chronic hypertension, gestational hypertension, preeclampsia/eclampsia, and preeclampsia superimposed on chronic hypertension. HDP complicate up to 10% of pregnancies worldwide and carry significant risks of maternal and perinatal morbidity and mortality. The aim of this study was to evaluate the derangement and characteristics of brachial artery flow-mediated dilation (BAFMD) in women with HDP.

METHODS

The BAFMD of the right brachial artery of 80 women with HDP (pregnant HDP), 80 normotensive pregnant women (pregnant non-HDP), and 80 healthy nonpregnant women (nonpregnant controls) was evaluated with B-mode ultrasound. The age, blood pressure, body mass index (BMI), brachial artery diameter, and BAFMD of the participants were compared. ≤ 0.05 was statistically significant.

RESULTS

The pregnant HDP group had significantly lower mean BAFMD compared to pregnant non-HDP and nonpregnant controls (6.9% ± 2.53% vs. 8.32% ± 3.4% vs. 9.4% ± 2.68%; < 0.001). There was no significant difference between the mean BAFMD of the pregnant HDP subgroups: preeclampsia (5.81% ± 1.7%) versus gestational hypertension (6.43% ± 3.02%); = 0.57. BAFMD diminished with advancing gestational age in both the pregnant HDP and pregnant non-HDP groups. On regression analysis, BAFMD was a poor marker for HDP, while BMI was an independent predictor for HDP.

CONCLUSION

Even though HDP were associated with significantly diminished BAFMD, it was not a good marker for HDP.

摘要

背景

妊娠期高血压疾病（HDP）包括慢性高血压、妊娠期高血压、子痫前期/子痫，以及慢性高血压并发子痫前期。HDP在全球高达10%的妊娠中出现并发症，并带来孕产妇和围产期发病及死亡的重大风险。本研究的目的是评估HDP女性肱动脉血流介导的血管舒张功能（BAFMD）的紊乱情况和特征。

方法

采用B型超声评估80例HDP孕妇（妊娠HDP组）、80例血压正常的孕妇（非妊娠HDP组）和80例健康非妊娠女性（非妊娠对照组）右侧肱动脉的BAFMD。比较参与者的年龄、血压、体重指数（BMI）、肱动脉直径和BAFMD。P≤0.05具有统计学意义。

结果

与非妊娠HDP组和非妊娠对照组相比，妊娠HDP组的平均BAFMD显著降低（6.9%±2.53% vs. 8.32%±3.4% vs. 9.4%±2.68%；P<0.001）。妊娠HDP亚组之间的平均BAFMD无显著差异：子痫前期（5.81%±1.7%）与妊娠期高血压（6.43%±3.02%）；P=0.57。在妊娠HDP组和非妊娠HDP组中，BAFMD均随孕周增加而降低。回归分析显示，BAFMD不是HDP的良好标志物，而BMI是HDP的独立预测因素。