Ayadi Shema, Monastiri Souhir, Safta Amine Ben, Hammami Mehdi, Samaali Imen, Kammoun Mehdi, Blel Ahlem, Aloui Raoudha, Zaimi Yosra, Mouelhi Leila
Gastroenterology Department, Charles Nicolle university hospital, Tunis, Tunisia.
Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Future Sci OA. 2024 Dec 31;10(1):FSO970. doi: 10.2144/fsoa-2023-0182. Epub 2024 Jun 17.
Breast cancer is the most frequent cancer among women. Gastrointestinal tract metastases are uncommon and might be misidentified as primary carcinoma.A noteworthy case-study involved 53-year-old-woman complaining from epigastric pain, ascites and overall health decline. Initial investigations were inconclusive, prompting laparoscopic peritoneal biopsies which revealed independent cell proliferation. Subsequently, a second look upper digestive endoscopy showed multiple gastric ulcerations suggestive of gastric carcinoma. Histologic examination confirmed independent cell proliferation with estrogen receptors expression, a characteristic feature of breast carcinoma. Further investigations led to bilateral invasive lobular breast carcinoma diagnosis. Epirubicin cycophosphamide was prescribed after progression under letrozole ribocilib therapy.This case aims to raise awareness among clinicians about the importance of ruling out breast cancer in patients with peritoneal carcinosis and paying attention to digestive symptoms in breast cancer patients with careful gastric endoscopic examination to avoid misdiagnosis.
乳腺癌是女性中最常见的癌症。胃肠道转移并不常见,可能会被误诊为原发性癌。一个值得注意的病例研究涉及一名53岁女性,她主诉上腹部疼痛、腹水和整体健康状况下降。初步检查结果不明确,于是进行了腹腔镜腹膜活检,结果显示有独立的细胞增殖。随后,再次进行的上消化道内镜检查显示有多处胃溃疡,提示为胃癌。组织学检查证实有独立的细胞增殖且存在雌激素受体表达,这是乳腺癌的一个特征性表现。进一步检查最终诊断为双侧浸润性小叶乳腺癌。在来曲唑联合瑞博西尼治疗病情进展后,给予了表柔比星环磷酰胺治疗。该病例旨在提高临床医生对以下两点的认识:一是在患有腹膜癌的患者中排除乳腺癌的重要性;二是对乳腺癌患者进行仔细的胃镜检查以关注消化症状,避免误诊。