Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dermatology Department, Clínica Alemana de Santiago - Facultad de Medicina Universidad del Desarrollo and Hospital Exequiel González Cortés, Santiago, Chile.
Pediatr Dermatol. 2024 Sep-Oct;41(5):936-937. doi: 10.1111/pde.15666. Epub 2024 Jun 17.
Giant congenital melanocytic nevi (GCMN) can be cosmetically significant and can lead to melanoma. There is no standard pharmacologic treatment for GCMN. We present the case of an 8-year-old female with kaposiform lymphangiomatosis caused by an NRAS mutation whose nevus spilus-type GCMN improved on oral selumetinib.
巨大先天性黑素细胞痣 (GCMN) 可能影响美观，并可导致黑色素瘤。目前 GCMN 尚无标准的药物治疗方法。我们报告了 1 例 8 岁女性患者，其因 NRAS 突变导致 Kaposiform 淋巴管瘤样增生，口服 selumetinib 后神经嵴来源痣样黑素细胞痣改善。
