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Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer.
Mol Ther. 2024 Jul 3;32(7):2080-2093. doi: 10.1016/j.ymthe.2024.05.004. Epub 2024 May 7.
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B cell focused transient immune suppression protocol for efficient AAV readministration to the liver.
Mol Ther Methods Clin Dev. 2024 Feb 20;32(1):101216. doi: 10.1016/j.omtm.2024.101216. eCollection 2024 Mar 14.
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Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme.
JCI Insight. 2020 Sep 17;5(19):139881. doi: 10.1172/jci.insight.139881.
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Neutralizing the Neutralizers in AAV Gene Therapy.
Mol Ther. 2020 Aug 5;28(8):1741-1742. doi: 10.1016/j.ymthe.2020.07.015. Epub 2020 Jul 21.
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IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies.
Nat Med. 2020 Jul;26(7):1096-1101. doi: 10.1038/s41591-020-0911-7. Epub 2020 Jun 1.
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B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny.
Clin Immunol. 2007 Feb;122(2):139-45. doi: 10.1016/j.clim.2006.08.009. Epub 2006 Sep 27.

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