Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dongcheng District, Beijing, 100730, PR China.
BMC Psychiatry. 2024 Jun 18;24(1):451. doi: 10.1186/s12888-024-05902-0.
Depression is a life-threatening mental health problem. Various factors have been demonstrated to be associated with depressive symptoms, including negative life events (NLEs) and alexithymia. A retrospective study was conducted to investigate the relationship among negative life events, alexithymia, and depression symptoms in a psychosomatic outpatient sample in China.
A total of 2747 outpatients (aged 18 - 65) were included in this investigation. The Life Events Scale (LES), Toronto alexithymia scale (TAS-26), and 9-item Patient Health Questionnaire (PHQ-9) were used to assess NLEs, alexithymia, and depressive symptoms, respectively. A stepwise regression analysis model was established to investigate the relationship among alexithymia, NLEs, and depressive symptoms.
Overall, 67.0% of the patient sample had a PHQ-9 score of 10 or higher. The stepwise regression analysis model showed a well-fitted model, in which NLEs and alexithymia explain a total of 34.2% of the variance of depressive symptoms in these participants. NLEs (β = 0.256, p < 0.001) and dimensions of alexithymia (difficult describing feelings (β = 0.192, p < 0.001) and identifying feelings (β = 0.308, p < 0.001)) were positively correlated with symptoms of depression.
Previous studies have confirmed the correlation between NLEs and depression, alexithymia and depression, respectively. In our study, we used a stepwise regression model to explain the relationship among those variables simultaneously, and found that NLEs and alexithymia could function as predictors of depressive symptoms. Based on this discovery, alexithymia-focused treatment strategies could be alternative in depressive patients with alexithymia, but this remains to be verified in the future.
抑郁症是一种危及生命的心理健康问题。各种因素已被证明与抑郁症状有关,包括负性生活事件(NLEs)和述情障碍。一项回顾性研究调查了中国心身门诊样本中负性生活事件、述情障碍与抑郁症状之间的关系。
本研究共纳入 2747 名门诊患者(年龄 18-65 岁)。使用生活事件量表(LES)、多伦多述情障碍量表(TAS-26)和 9 项患者健康问卷(PHQ-9)分别评估 NLEs、述情障碍和抑郁症状。建立逐步回归分析模型来探讨述情障碍、NLEs 和抑郁症状之间的关系。
总体而言,67.0%的患者 PHQ-9 评分≥10 分。逐步回归分析模型显示,该模型拟合良好,NLEs 和述情障碍共解释了这些参与者抑郁症状总变异的 34.2%。NLEs(β=0.256,p<0.001)和述情障碍维度(难以描述感受(β=0.192,p<0.001)和识别感受(β=0.308,p<0.001))与抑郁症状呈正相关。
先前的研究已经证实了 NLEs 与抑郁、述情障碍与抑郁之间的相关性。在我们的研究中,我们使用逐步回归模型同时解释这些变量之间的关系,发现 NLEs 和述情障碍可以作为抑郁症状的预测因子。基于这一发现,针对述情障碍的治疗策略可能是患有述情障碍的抑郁患者的另一种选择,但这仍有待未来验证。