Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita City, Japan.
Department of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan.
BMC Prim Care. 2024 Jun 18;25(1):219. doi: 10.1186/s12875-024-02449-7.
It is unclear how primary care physicians manage insomnia after the introduction of novel hypnotics such as orexin receptor antagonists and melatonin receptor agonists. This Web-based questionnaire survey aimed to examine treatment strategies for insomnia in Japanese primary care practice.
One-hundred-and-seventeen primary care physicians were surveyed on the familiarity of each management option for insomnia on a binary response scale (0 = "unfamiliar"; 1 = "familiar") and how they managed insomnia using a nine-point Likert scale (1 = "I never prescribe/perform it"; 9 = "I often prescribe/perform it"). Physicians who were unfamiliar with a management option were deemed to have never prescribed or performed it.
Regarding medication, most physicians were familiar with novel hypnotics. Suvorexant was the most used hypnotic, followed by lemborexant and ramelteon. These novel hypnotics averaged 4.8-5.4 points and 4.0-4.7 points for sleep onset and sleep maintenance insomnia, respectively. By contrast, most benzodiazepines were seldom used below two points. Regarding psychotherapy, only approximately 40% of the physicians were familiar with cognitive behavioral therapy for insomnia (CBT-I) and they rarely implemented it, at an average of 1.5-1.6 points. More physicians were familiar with single-component psychotherapies (i.e., relaxation, sleep restriction therapy, and stimulus control) compared to CBT-I, and 48-74% of them implemented it slightly more often, with scores ranging from 2.6 to 3.4 points.
This study suggests that Japanese primary care physicians seldom use CBT-I to treat insomnia. In addition, they use novel sleep medications more frequently than benzodiazepines in terms of pharmacotherapy. The use and availability of CBT-I in Japanese primary care might be facilitated by: educating primary care physicians, implementing brief or digital CBT-I, and/or developing collaborations between primary care physicians and CBT-I specialists.
在新型催眠药物(如食欲素受体拮抗剂和褪黑素受体激动剂)问世后,初级保健医生如何治疗失眠尚不清楚。本项基于网络的问卷调查旨在考察日本初级保健实践中失眠的治疗策略。
采用二项反应量表(0=不熟悉;1=熟悉)对 171 名初级保健医生进行失眠每种治疗选择的熟悉程度调查,并采用 9 分 Likert 量表(1=我从不开具/执行;9=我经常开具/执行)调查他们对失眠的处理方法。对不熟悉某种治疗方法的医生,视为未曾开具或执行过该治疗方法。
在药物治疗方面,大多数医生对新型催眠药物比较熟悉。苏沃雷生是使用最多的催眠药物,其次是仑贝格雷生和雷美尔酮。这些新型催眠药物对入睡和维持睡眠失眠的平均评分为 4.8-5.4 分和 4.0-4.7 分。相比之下,大多数苯二氮䓬类药物的使用频率很少低于 2 分。在心理治疗方面,只有约 40%的医生熟悉失眠的认知行为疗法(CBT-I),且很少实施,平均评分为 1.5-1.6 分。与 CBT-I 相比,更多的医生熟悉单一成分的心理治疗(即放松、睡眠限制疗法和刺激控制),且有 48%-74%的医生略为更常实施,评分在 2.6-3.4 分之间。
本研究表明,日本初级保健医生很少使用 CBT-I 治疗失眠。此外,在药物治疗方面,他们使用新型睡眠药物比苯二氮䓬类药物更为频繁。通过对初级保健医生进行教育、实施简短或数字化的 CBT-I,以及/或者在初级保健医生和 CBT-I 专家之间建立合作关系,可能会促进日本初级保健中 CBT-I 的使用和普及。