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无诱因静脉血栓栓塞复发及动脉栓塞提示肺癌:一例报告

Unprovoked venous thromboembolism recurrence and arterial embolism revealing lung cancer: a case report.

作者信息

Glodeanu Maria-Cristina, Mutruc Victoria, Apetrei Camelia-Maria, Ursaru Manuela, Sorodoc Laurentiu, Lionte Catalina

机构信息

2nd Internal Medicine Clinic, "Sf. Spiridon" Emergency Clinical County Hospital, Iasi, Romania.

Rheumatology Department, Clinical Recovery Hospital, Iasi, Romania.

出版信息

Thromb J. 2024 Jun 18;22(1):51. doi: 10.1186/s12959-024-00622-7.

Abstract

The link between venous thromboembolism (VTE) and cancer is well known. VTE could be the initial sign of an occult malignancy. There are more diagnoses of cancer after an unprovoked VTE compared to a provoked VTE, with a reported prevalence between 4.5% and 5.6% over 12 months, within the first 6 months of VTE diagnosis. There are no recommended guidelines and scores yet adopted in clinical practice, but many studies support occult cancer screening in unprovoked VTE patients. We report the case of a patient with a history of unprovoked pulmonary embolism (PE) diagnosed with bronchopulmonary neoplasm in an advanced stage one year after the thromboembolic event. When the cancer was first diagnosed, the patient's condition was already serious, being too late for the adoption of measures meant to decrease the risk of mortality and increase the duration of survival. We wanted to emphasize the importance of occult cancer screening in patients with unprovoked VTE and the fact that early cancer diagnosis reduces the risk of cancer progression, decreasing mortality and morbidity related to it.

摘要

静脉血栓栓塞症(VTE)与癌症之间的联系众所周知。VTE可能是隐匿性恶性肿瘤的初始迹象。与有诱因的VTE相比,无诱因的VTE后癌症诊断更多,据报道在VTE诊断后的前6个月内,12个月内癌症患病率在4.5%至5.6%之间。临床实践中尚未采用推荐的指南和评分,但许多研究支持对无诱因VTE患者进行隐匿性癌症筛查。我们报告了一例有无诱因肺栓塞(PE)病史的患者,在血栓栓塞事件发生一年后被诊断为晚期支气管肺肿瘤。当首次诊断出癌症时,患者的病情已经很严重,采取降低死亡风险和延长生存时间的措施为时已晚。我们想强调对无诱因VTE患者进行隐匿性癌症筛查的重要性,以及早期癌症诊断可降低癌症进展风险、降低与之相关的死亡率和发病率这一事实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6491/11186263/3a29323c4b90/12959_2024_622_Fig1_HTML.jpg

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