Private Dermatology Practice, Zürich, Switzerland.
Private Practice, Athens, Greece.
J Cosmet Dermatol. 2024 Aug;23(8):2543-2546. doi: 10.1111/jocd.16419. Epub 2024 Jun 18.
Hyaluronic acids (HAs) can have very different actions not only depending on injector and host factors but also depending on their molecular weight. Whereas short chain HA has immunological activity long chain HA influences fibroblasts and may stimulate them to produce collagen. Although this is generally thought to be a positive feature it may be disadvantageous in certain localizations.
We have encountered 23 patients who developed fibrous tissue next to the nasolabial folds accentuating them and becoming very obvious while smiling. Hyaluronidase injection did not reduce this mass.
Intralesional triamcinolone acetonide injection led to rapid improvement.
Fibrotic tissue reaction not responding to hyaluronidase may be the result of HA injection and can effectively be treated with intralesional steroid injection.
透明质酸（HA）的作用不仅取决于注射者和宿主因素，还取决于其分子量。短链 HA 具有免疫活性，长链 HA 则影响成纤维细胞，并可能刺激其产生胶原蛋白。尽管这通常被认为是一个积极的特征，但在某些部位可能不利。
我们遇到了 23 名患者，他们在鼻唇沟附近出现纤维组织，使鼻唇沟更加明显，尤其是在微笑时。透明质酸酶注射并不能减少这种肿块。
局部注射曲安奈德迅速改善。
对透明质酸酶无反应的纤维组织反应可能是 HA 注射的结果，局部类固醇注射可有效治疗。
