Ghani Israr, An Yuxuan, Qiao Qinqin, He Shuiling, Li Zhuoyu
Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, China.
Foods. 2024 May 27;13(11):1683. doi: 10.3390/foods13111683.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. The burden of NAFLD is increasing at an alarming rate. NAFLD is frequently associated with morbidities such as dyslipidemia, type 2 diabetes mellitus and obesity, etc. The current study explored the potential role of in treating mice with NAFLD induced by a high-fat diet (HFD). The results indicated the critical role of BPIS in treating NAFLD by effectively restoring the gut microbiota in C57BL/6 mice that received a high-fat diet (HFD) for 12 weeks. At the same time, 16S rRNA analysis demonstrated that BPIS remodeled the overall structure of the gut microbiota from fatty liver diseases towards that of normal counterparts, including ten phylum and twenty genus levels. Further study found that the expression of tight junction proteins was upregulated in the BPIS-treated group. This study provides new insights into the potential NAFLD protective effects induced by polyphenols of foxtail millet.
非酒精性脂肪性肝病（NAFLD）是代谢功能障碍最常见的慢性肝脏表现，目前缺乏有效的干预措施。NAFLD的负担正以惊人的速度增加。NAFLD常与血脂异常、2型糖尿病和肥胖等疾病相关。本研究探讨了[具体物质未给出]在治疗高脂饮食（HFD）诱导的NAFLD小鼠中的潜在作用。结果表明，BPIS通过有效恢复接受12周高脂饮食（HFD）的C57BL/6小鼠的肠道微生物群，在治疗NAFLD中起关键作用。同时，16S rRNA分析表明，BPIS将肠道微生物群的整体结构从脂肪肝疾病重塑为正常对照的结构，包括十个门和二十个属水平。进一步研究发现，BPIS治疗组紧密连接蛋白的表达上调。本研究为谷子多酚对NAFLD的潜在保护作用提供了新的见解。
