• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

谷子麸皮中的多酚通过重塑肠道微生物群改善葡聚糖硫酸钠诱导的结肠炎。

Polyphenols from foxtail millet bran ameliorate DSS-induced colitis by remodeling gut microbiome.

作者信息

Yang Ruipeng, Shan Shuhua, An Ning, Liu Fengming, Cui Kaili, Shi Jiangying, Li Hanqing, Li Zhuoyu

机构信息

Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, China.

School of Life Science, Shanxi University, Taiyuan, China.

出版信息

Front Nutr. 2022 Nov 21;9:1030744. doi: 10.3389/fnut.2022.1030744. eCollection 2022.

DOI:10.3389/fnut.2022.1030744
PMID:36479296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9719911/
Abstract

INTRODUCTION

Polyphenols from plants possess the anti-inflammatory and gut microbiota modulated properties. Foxtail millet ( L., FM) has potential medical and nutritional functions because of rich phenolic and other phytochemical components.

METHODS

Here, the study explored the effects of bound polyphenol of inner shell (BPIS) from FM bran on dextran sodium sulfate (DSS)-induced experimental colitis mice.

RESULTS

Results showed that BPIS administration effectively relieved the weight loss, decreased disease active index (DAI) scores, restrained the secretion of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β, increased anti-inflammatory cytokines IL-10, IL-4, IL-5. BPIS prevented gut barrier damage by enhancing tight junction proteins Claudin1, ZO-1 and Occludin, increasing the number of goblet cells and facilitating the gene expressions of mucin family. In addition, BPIS restored the gut microbiota composition and increased the relative abundance of commensal bacteria such as and and restrained the growth of and . Concentrations of short-chain-fatty acids (SCFAs) generated by gut microbiota were elevated in BPIS treated colitis mice.

CONCLUSION

These data suggest that BPIS effectively ameliorates DSS-induced colitis by preventing intestinal barrier damage and promoting gut microbiota community.

摘要

引言

植物多酚具有抗炎和调节肠道微生物群的特性。由于富含酚类和其他植物化学成分，谷子（L.，FM）具有潜在的医学和营养功能。

方法

本研究探讨了谷子麸皮内壳结合多酚（BPIS）对葡聚糖硫酸钠（DSS）诱导的实验性结肠炎小鼠的影响。

结果

结果表明，给予BPIS可有效缓解体重减轻，降低疾病活动指数（DAI）评分，抑制促炎细胞因子TNF-α、IL-6和IL-1β的分泌，增加抗炎细胞因子IL-10、IL-4、IL-5。BPIS通过增强紧密连接蛋白Claudin1、ZO-1和Occludin，增加杯状细胞数量并促进粘蛋白家族的基因表达，防止肠道屏障损伤。此外，BPIS恢复了肠道微生物群组成，增加了共生细菌如和的相对丰度，并抑制了和的生长。在BPIS治疗的结肠炎小鼠中，肠道微生物群产生的短链脂肪酸（SCFAs）浓度升高。

结论

这些数据表明，BPIS通过防止肠道屏障损伤和促进肠道微生物群群落，有效改善了DSS诱导的结肠炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/42eb2a2290aa/fnut-09-1030744-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/22e7597343dd/fnut-09-1030744-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/9722735daba3/fnut-09-1030744-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/93d7c7d40f59/fnut-09-1030744-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/d1362347439a/fnut-09-1030744-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/7c8455e088ba/fnut-09-1030744-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/312be956cdc4/fnut-09-1030744-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/42eb2a2290aa/fnut-09-1030744-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/22e7597343dd/fnut-09-1030744-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/9722735daba3/fnut-09-1030744-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/93d7c7d40f59/fnut-09-1030744-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/d1362347439a/fnut-09-1030744-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/7c8455e088ba/fnut-09-1030744-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/312be956cdc4/fnut-09-1030744-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe84/9719911/42eb2a2290aa/fnut-09-1030744-g0007.jpg

相似文献

1
Polyphenols from foxtail millet bran ameliorate DSS-induced colitis by remodeling gut microbiome.谷子麸皮中的多酚通过重塑肠道微生物群改善葡聚糖硫酸钠诱导的结肠炎。
Front Nutr. 2022 Nov 21;9:1030744. doi: 10.3389/fnut.2022.1030744. eCollection 2022.
2
Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in a Mice Model.粟米糠中结合态多酚通过恢复小鼠模型肠道菌群对结肠炎相关癌变的抑制作用
J Agric Food Chem. 2020 Mar 18;68(11):3506-3517. doi: 10.1021/acs.jafc.0c00370. Epub 2020 Mar 5.
3
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside, a major bioactive component from Polygoni multiflori Radix (Heshouwu) suppresses DSS induced acute colitis in BALb/c mice by modulating gut microbiota.2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷，何首乌的主要生物活性成分，通过调节肠道微生物群抑制 DSS 诱导的 BALb/c 小鼠急性结肠炎。
Biomed Pharmacother. 2021 May;137:111420. doi: 10.1016/j.biopha.2021.111420. Epub 2021 Feb 23.
4
Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity.白头翁汤通过调节粪便细菌相关的短链脂肪酸和肠道屏障完整性改善 DSS 诱导的结肠炎。
J Ethnopharmacol. 2023 Jan 10;300:115741. doi: 10.1016/j.jep.2022.115741. Epub 2022 Sep 24.
5
Supplementation With Chinese Medicinal Plant Extracts From and Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model.中药提取物 和 对结肠炎模型小鼠的结肠炎症具有缓解作用，其机制与调控氧化应激和肠道菌群有关。
Front Cell Infect Microbiol. 2022 Jan 4;11:798052. doi: 10.3389/fcimb.2021.798052. eCollection 2021.
6
Apigenin remodels the gut microbiota to ameliorate ulcerative colitis.芹菜素重塑肠道微生物群以改善溃疡性结肠炎。
Front Nutr. 2022 Dec 16;9:1062961. doi: 10.3389/fnut.2022.1062961. eCollection 2022.
7
The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death.粟米（Setaria italica）内壳结合的多酚通过促进脂类积累诱导的自噬性死亡来抑制乳腺癌。
Food Chem Toxicol. 2023 Jul;177:113855. doi: 10.1016/j.fct.2023.113855. Epub 2023 May 23.
8
Pediococcus pentosaceus CECT 8330 protects DSS-induced colitis and regulates the intestinal microbiota and immune responses in mice.戊糖片球菌 CECT8330 可保护 DSS 诱导的结肠炎，并调节小鼠的肠道微生物群和免疫反应。
J Transl Med. 2022 Jan 15;20(1):33. doi: 10.1186/s12967-022-03235-8.
9
Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota.烟酰胺通过其抗炎特性和调节肠道微生物群来减轻葡聚糖硫酸钠诱导的小鼠慢性结肠炎。
J Immunol Res. 2021 Mar 6;2021:5084713. doi: 10.1155/2021/5084713. eCollection 2021.
10
Wheat Bran Polyphenols Ameliorate DSS-Induced Ulcerative Colitis in Mice by Suppressing MAPK/NF-κB Inflammasome Pathways and Regulating Intestinal Microbiota.麦麸多酚通过抑制MAPK/NF-κB炎性小体途径和调节肠道微生物群来改善DSS诱导的小鼠溃疡性结肠炎。
Foods. 2024 Jan 10;13(2):225. doi: 10.3390/foods13020225.

引用本文的文献

1
The Effect of Different Processing Methods on Metabolite Profiles by Comparative Metabolomics in Kernels and Sprouted Seeds of Foxtail Millet.不同加工方法对谷子籽粒和发芽种子代谢物谱的影响：基于比较代谢组学研究
Foods. 2025 May 27;14(11):1900. doi: 10.3390/foods14111900.
2
Potential of Fiber and Probiotics to Fight Against the Effects of PhIP + DSS-Induced Carcinogenic Process of the Large Intestine.膳食纤维和益生菌对抗 PhIP+DSS 诱导的大肠癌变过程的潜力。
J Agric Food Chem. 2024 Nov 13;72(45):25161-25172. doi: 10.1021/acs.jafc.4c07366. Epub 2024 Oct 29.
3
Coumarin derivatives ameliorate the intestinal inflammation and pathogenic gut microbiome changes in the model of infectious colitis through antibacterial activity.

本文引用的文献

1
Anti-hyperlipidemic and ameliorative effects of chickpea starch and resistant starch in mice with high fat diet induced obesity are associated with their multi-scale structural characteristics.鹰嘴豆淀粉和抗性淀粉通过多尺度结构特性对高脂肪饮食诱导肥胖小鼠的降脂及改善作用。
Food Funct. 2022 May 10;13(9):5135-5152. doi: 10.1039/d1fo04354d.
2
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease.2 型免疫在肠道稳态和炎症性肠病中的作用。
Biochem Soc Trans. 2021 Nov 1;49(5):2371-2380. doi: 10.1042/BST20210535.
3
Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora.
香豆素衍生物通过抗菌活性改善感染性结肠炎模型中的肠道炎症和致病肠道微生物组变化。
Front Cell Infect Microbiol. 2024 Jul 15;14:1362773. doi: 10.3389/fcimb.2024.1362773. eCollection 2024.
4
Polyphenols from Foxtail Millet Improve Non-Alcoholic Fatty Liver Disease by Regulating Intestinal Microbiome in Mice.谷子中的多酚通过调节小鼠肠道微生物群改善非酒精性脂肪性肝病。
Foods. 2024 May 27;13(11):1683. doi: 10.3390/foods13111683.
5
Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens.迷迭香叶粉可改善后期产蛋母鸡的蛋品质、抗氧化状态、肠道屏障功能以及盲肠微生物群和代谢产物。
Anim Nutr. 2024 Mar 19;17:325-334. doi: 10.1016/j.aninu.2024.02.003. eCollection 2024 Jun.
6
Microbial dysbiosis index for assessing colitis status in mouse models: A systematic review and meta-analysis.用于评估小鼠模型结肠炎状态的微生物失调指数：系统评价与荟萃分析
iScience. 2023 Dec 6;27(1):108657. doi: 10.1016/j.isci.2023.108657. eCollection 2024 Jan 19.
7
Polyphenols Attenuate DSS-induced Ulcerative Colitis in Mice via Antioxidation, Anti-inflammation and Microbiota Regulation.多酚通过抗氧化、抗炎和调节微生物群减轻 DSS 诱导的小鼠溃疡性结肠炎。
Int J Mol Sci. 2023 Jun 29;24(13):10828. doi: 10.3390/ijms241310828.
用于调节肠道免疫和菌群的结肠靶向黏附水凝胶微球。
Adv Sci (Weinh). 2021 Sep;8(18):e2101619. doi: 10.1002/advs.202101619. Epub 2021 Jul 22.
4
Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation.膳食大麦叶补充物来源的肠道微生物组衍生次黄嘌呤通过激活 PPARγ 信号减轻结肠炎。
Microbiome. 2021 Apr 5;9(1):83. doi: 10.1186/s40168-021-01028-7.
5
Diet supporting therapy for inflammatory bowel diseases.炎症性肠病的饮食支持治疗。
Eur J Nutr. 2021 Aug;60(5):2275-2291. doi: 10.1007/s00394-021-02489-0. Epub 2021 Mar 31.
6
The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease.益生菌对肥胖症和炎症性肠病治疗中厚壁菌门/拟杆菌门比例的影响
Microorganisms. 2020 Nov 1;8(11):1715. doi: 10.3390/microorganisms8111715.
7
Angiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae.血管生成素通过平衡 α-变形菌门和lachnospiraceae 来维持肠道微生物组稳态。
Gut. 2021 Apr;70(4):666-676. doi: 10.1136/gutjnl-2019-320135. Epub 2020 Aug 25.
8
Review of whole grain and dietary fiber recommendations and intake levels in different countries.不同国家全谷物和膳食纤维推荐摄入量和实际摄入量的综述。
Nutr Rev. 2020 Aug 1;78(Suppl 1):29-36. doi: 10.1093/nutrit/nuz052.
9
Dietary Quercetin Alleviated DSS-induced Colitis in Mice Through Several Possible Pathways by Transcriptome Analysis.通过转录组分析发现，膳食槲皮素通过多种可能的途径缓解了 DSS 诱导的小鼠结肠炎。
Curr Pharm Biotechnol. 2020;21(15):1666-1673. doi: 10.2174/1389201021666200711152726.
10
A purified membrane protein from or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 T cells in mice.来自或巴氏杀菌细菌的纯化膜蛋白通过调节小鼠的 CD8 T 细胞来减弱结肠炎相关的肿瘤发生。
Gut. 2020 Nov;69(11):1988-1997. doi: 10.1136/gutjnl-2019-320105. Epub 2020 Mar 13.