Ahn Yu-Jin, Kim Boyun, Kim Yoon Hee, Kim Tae Young, Seo Hyeyeong, Park Yooheon, Park Sung-Soo, Ahn Yejin
Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.
Department of Smart-Bio, Kyungsung University, Busan 48434, Republic of Korea.
Foods. 2024 May 31;13(11):1725. doi: 10.3390/foods13111725.
Long-term hepatic damage is associated with human morbidity and mortality owing to numerous pathogenic factors. A variety of studies have focused on improving liver health using natural products and herbal medicines. We aimed to investigate the effect of enzyme-treated ethanol extract (ETZL), which increases the content of tricin via enzymatic hydrolysis, for 8 weeks on liver-related outcomes, lipid metabolism, antioxidant activity, and fatigue compared to a placebo. Healthy Korean adult males aged 19-60 years were randomized into ETZL treatment and placebo groups, and alcohol consumption was 24.96 and 28.64 units/week, respectively. Alanine transaminase, a blood marker associated with liver cell injury, significantly decreased after 8 weeks compared to the baseline in the ETZL treatment group ( = 0.004). After 8 weeks, the treatment group showed significant changes in the levels of high-density lipoprotein and hepatic steatosis index compared to the baseline ( = 0.028 and = 0.004, respectively). ETZL treatment tended to reduce antioxidant-activity-related factors, total antioxidant status, and malondialdehyde, but there was no significant difference. In the multidimensional fatigue scale, ETZL treatment showed a significant reduction in general fatigue and total-fatigue-related values after 8 weeks compared to the baseline ( = 0.012 and = 0.032, respectively). Taken together, the 8-week treatment of enzyme-treated ethanol extract demonstrated positive effects on liver-related outcomes, lipid metabolism, and mental fatigue without adverse effects on safety-related parameters.
由于多种致病因素，长期肝损伤与人类发病率和死亡率相关。各种研究都集中在使用天然产物和草药来改善肝脏健康。我们旨在研究经酶处理的乙醇提取物（ETZL），其通过酶促水解增加了小麦黄素的含量，与安慰剂相比，连续8周对肝脏相关指标、脂质代谢、抗氧化活性和疲劳的影响。19至60岁的健康韩国成年男性被随机分为ETZL治疗组和安慰剂组，每周酒精摄入量分别为24.96和28.64单位。与肝细胞损伤相关的血液标志物丙氨酸转氨酶在ETZL治疗组中8周后与基线相比显著降低（P = 0.004）。8周后，治疗组与基线相比，高密度脂蛋白水平和肝脏脂肪变性指数有显著变化（分别为P = 0.028和P = 0.004）。ETZL治疗倾向于降低与抗氧化活性相关的因素、总抗氧化状态和丙二醛，但没有显著差异。在多维疲劳量表中，ETZL治疗在8周后与基线相比，一般疲劳和总疲劳相关值显著降低（分别为P = 0.012和P = 0.032）。综上所述，经酶处理的乙醇提取物8周治疗对肝脏相关指标、脂质代谢和精神疲劳显示出积极作用，且对安全相关参数无不良影响。
