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（-）-表没食子儿没食子酸酯减轻小鼠代谢综合征相关的糖尿病肾病

(-)-Gallocatechin Gallate Mitigates Metabolic Syndrome-Associated Diabetic Nephropathy in Mice.

作者信息

Xiao Xin, Ge Huifang, Wang Yijun, Wan Xiaochun, Li Daxiang, Xie Zhongwen

机构信息

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei 230036, China.

Joint Research Center for Food Nutrition and Health of IHM, Hefei 230036, China.

出版信息

Foods. 2024 Jun 3;13(11):1755. doi: 10.3390/foods13111755.

DOI:10.3390/foods13111755
PMID:38890983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11171689/
Abstract

Metabolic syndrome (MetS) significantly predisposes individuals to diabetes and is a prognostic factor for the progression of diabetic nephropathy (DN). This study aimed to evaluate the efficacy of (-)-gallocatechin gallate (GCG) in alleviating signs of MetS-associated DN in mice. We administered GCG and monitored its effects on several metabolic parameters, including food and water intake, urinary output, blood glucose levels, glucose and insulin homeostasis, lipid profiles, blood pressure, and renal function biomarkers. The main findings indicated that GCG intervention led to marked improvements in these metabolic indicators and renal function, signifying its potential in managing MetS and DN. Furthermore, transcriptome analysis revealed substantial modifications in gene expression, notably the downregulation of pro-inflammatory genes such as , , , , , , , -, , , and and the upregulation of the anti-oxidative gene . These genetic alterations suggest significant effects on pathways related to inflammation and oxidative stress. In conclusion, GCG demonstrates therapeutic efficacy for MetS-associated DN, mitigating metabolic disturbances and enhancing renal health by modulating inflammatory and oxidative responses.

摘要

代谢综合征（MetS）显著增加个体患糖尿病的风险，并且是糖尿病肾病（DN）进展的一个预后因素。本研究旨在评估（-）-没食子儿茶素没食子酸酯（GCG）在减轻小鼠MetS相关DN症状方面的疗效。我们给予GCG并监测其对多个代谢参数的影响，包括食物和水摄入量、尿量、血糖水平、葡萄糖和胰岛素稳态、血脂谱、血压以及肾功能生物标志物。主要研究结果表明，GCG干预使这些代谢指标和肾功能有显著改善，表明其在管理MetS和DN方面的潜力。此外，转录组分析显示基因表达有大量改变，特别是促炎基因如[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]、[此处原文未列出具体基因名称]和[此处原文未列出具体基因名称]的下调以及抗氧化基因[此处原文未列出具体基因名称]的上调。这些基因改变表明对与炎症和氧化应激相关的途径有显著影响。总之，GCG对MetS相关DN具有治疗效果，通过调节炎症和氧化反应减轻代谢紊乱并增强肾脏健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/0b157026138f/foods-13-01755-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/49d862eb9298/foods-13-01755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/43c6a98bad7f/foods-13-01755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/cce29ed4114a/foods-13-01755-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/fe55d0103bf0/foods-13-01755-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/9fa691805a2d/foods-13-01755-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/0b157026138f/foods-13-01755-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/49d862eb9298/foods-13-01755-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/43c6a98bad7f/foods-13-01755-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/cce29ed4114a/foods-13-01755-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/fe55d0103bf0/foods-13-01755-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/9fa691805a2d/foods-13-01755-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db4c/11171689/0b157026138f/foods-13-01755-g006.jpg

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