文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

吸烟对端粒长度、致癌应激诱导和导致衰老的慢性炎症反应的影响。

The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging.

机构信息

Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA.

Department of Pathology, UW Health SwedishAmerican Hospital, Rockford, IL 61107, USA.

出版信息

Cells. 2024 May 21;13(11):884. doi: 10.3390/cells13110884.

DOI:10.3390/cells13110884
PMID:38891017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11172003/
Abstract

Telomeres, potential biomarkers of aging, are known to shorten with continued cigarette smoke exposure. In order to further investigate this process and its impact on cellular stress and inflammation, we used an in vitro model with cigarette smoke extract (CSE) and observed the downregulation of telomere stabilizing and genes after CSE treatment. is a subunit of telomerase and a well-known oncogenic marker, which is overexpressed in over 85% of cancers and may contribute to lung cancer development in smokers. We also observed an increase in and expression levels after CSE treatment, as well as increased protein levels revealed by immunohistochemical staining in smokers' lung tissue samples compared to non-smokers. The effects of overexpression were further studied by quantifying , an inflammatory protein induced by , which showed greater upregulation in smokers compared to non-smokers. Similar changes in gene expression patterns for , , , and were observed in blood and buccal swab samples from smokers compared to non-smokers. The results from this study provide insight into the mechanisms behind smoking causing telomere shortening and how this may contribute to the induction of inflammation and/or tumorigenesis, which may lead to comorbidities in smokers.

摘要

端粒是衰老的潜在生物标志物，已知随着持续的香烟烟雾暴露而缩短。为了进一步研究这个过程及其对细胞应激和炎症的影响，我们使用了香烟烟雾提取物（CSE）的体外模型，并观察到 CSE 处理后端粒稳定和基因的下调。 是端粒酶的亚基，是一种众所周知的致癌标志物，在超过 85%的癌症中过度表达，可能导致吸烟者肺癌的发生。我们还观察到 CSE 处理后 和 表达水平增加，与非吸烟者相比，吸烟者肺组织样本中的免疫组织化学染色显示蛋白质水平也增加。通过定量分析 ，进一步研究了 过表达的影响， 是由 诱导的一种炎症蛋白，吸烟者中的上调幅度大于非吸烟者。与非吸烟者相比，吸烟者的血液和口腔拭子样本中也观察到 、 、 和 的基因表达模式发生类似变化。这项研究的结果深入了解了吸烟导致端粒缩短的机制，以及这如何导致炎症和/或肿瘤发生的诱导，这可能导致吸烟者出现合并症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/9dcb24c26cd9/cells-13-00884-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/a19af8f95eaa/cells-13-00884-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/6baa912c2df7/cells-13-00884-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/dd0247b49321/cells-13-00884-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/16ec8ef66a62/cells-13-00884-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/54fc3373a071/cells-13-00884-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/b38fc00e7375/cells-13-00884-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/1ee78bd2188f/cells-13-00884-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/dd6e4ce6aee3/cells-13-00884-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/06c0c4e25fb3/cells-13-00884-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/f23eb0dadde7/cells-13-00884-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/9dcb24c26cd9/cells-13-00884-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/a19af8f95eaa/cells-13-00884-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/6baa912c2df7/cells-13-00884-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/dd0247b49321/cells-13-00884-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/16ec8ef66a62/cells-13-00884-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/54fc3373a071/cells-13-00884-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/b38fc00e7375/cells-13-00884-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/1ee78bd2188f/cells-13-00884-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/dd6e4ce6aee3/cells-13-00884-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/06c0c4e25fb3/cells-13-00884-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/f23eb0dadde7/cells-13-00884-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175c/11172003/9dcb24c26cd9/cells-13-00884-g011.jpg

相似文献

[1]
The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging.

Cells. 2024-5-21

[2]
Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers.

J Hepatol. 2013-5-14

[3]
In vivo stoichiometry of shelterin components.

J Biol Chem. 2009-10-28

[4]
Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas.

Cancer Med. 2012-7-24

[5]
TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhang.

Nucleic Acids Res. 2021-12-2

[6]
A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes.

Retrovirology. 2005-12-15

[7]
TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.

Mol Cell Biol. 2014-1-27

[8]
Shelterin dysfunction promotes CD4+ T cell senescence in Behçet's disease.

Rheumatology (Oxford). 2024-10-1

[9]
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.

Nat Commun. 2017-10-20

[10]
Telomere length regulates ISG15 expression in human cells.

Aging (Albany NY). 2009-7-17

引用本文的文献

[1]
Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression.

Front Oncol. 2025-5-29

[2]
Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes.

JAMA Netw Open. 2025-5-1

[3]
Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil.

J Bras Pneumol. 2025-1-13

本文引用的文献

[1]
The Altered Functions of Shelterin Components in ALT Cells.

Int J Mol Sci. 2023-11-27

[2]
Pot1b -/- tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation.

Nucleic Acids Res. 2023-9-22

[3]
The diverse repertoire of ISG15: more intricate than initially thought.

Exp Mol Med. 2022-11

[4]
ISG15 and ISGylation in Human Diseases.

Cells. 2022-2-4

[5]
Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.

J Clin Med. 2021-12-24

[6]
Promoter Mutations Increase Sense and Antisense Transcription from the Promoter.

Biomedicines. 2021-11-26

[7]
Regulation of Gene Expression by Telomere Position Effect.

Int J Mol Sci. 2021-11-26

[8]
The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response.

Int J Mol Sci. 2021-9-14

[9]
Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition.

Cells. 2021-7-11

[10]
Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review).

Oncol Rep. 2021-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索