Godfrey N, Kumar A, Bing R F, Swales J D, Thurston H
J Lab Clin Med. 1985 Jun;105(6):679-85.
Blood pressure changes produced by removal of the renal artery clip in two forms of experimental renovascular hypertension in the rat (two-kidney one-clip and one-kidney one-clip hypertension) have been studied in relation to sodium balance and the renin angiotensin system. Continuous records of arterial blood pressure in conscious, freely moving animals with hypertension of less than 6 weeks' duration showed similar baseline values. After unclipping, blood pressure fell to normal levels within 12 hours of operation, and the pattern of the fall was identical in both models. Plasma renin concentration was elevated in two-kidney hypertension and fell to normal by 24 hours after operation, remaining unchanged 6 days later, whereas in one-kidney hypertension it was normal before and after unclipping. Sodium balance became positive in two-kidney hypertension within 24 hours of unclipping and remained so at 7 days, and was significantly different from that in unclipped loose-clip controls (+2.54 +/- 0.55 mmol vs. +0.46 +/- 0.55 mmol at 7 days, P less than 0.05). In one-kidney hypertension, sodium balance was negative during the first 24 hours after operation, and remained slightly negative at 7 days compared with loose-clip controls (-0.34 +/- 0.23 mmol). The similarity in the pattern of blood pressure fall in these two models of renovascular hypertension, despite qualitative differences in the response of sodium balance and the renin-angiotensin system, suggests that a common mechanism is activated by unclipping. This mechanism cannot be explained solely in terms of changes in sodium balance or activity of the renin-angiotensin system.
在大鼠的两种实验性肾血管性高血压（两肾一夹和一肾一夹高血压）中，移除肾动脉夹所产生的血压变化已与钠平衡及肾素 - 血管紧张素系统相关联进行了研究。对清醒、自由活动且高血压病程小于6周的动物的动脉血压进行连续记录，结果显示相似的基线值。松开夹子后，血压在术后12小时内降至正常水平，且两种模型中血压下降的模式相同。在两肾性高血压中，血浆肾素浓度升高，术后24小时降至正常，6天后保持不变；而在一肾性高血压中，松开夹子前后血浆肾素浓度均正常。在两肾性高血压中，松开夹子后24小时内钠平衡变为正值，并在7天时保持如此，且与未夹闭的松开夹子对照组显著不同（7天时为 +2.54 ± 0.55 mmol 对 +0.46 ± 0.55 mmol，P < 0.05）。在一肾性高血压中，术后最初24小时内钠平衡为负值，与松开夹子对照组相比，7天时仍略为负值（-0.34 ± 0.23 mmol）。这两种肾血管性高血压模型中血压下降模式的相似性，尽管钠平衡和肾素 - 血管紧张素系统的反应存在质的差异，提示松开夹子激活了一种共同机制。这种机制不能仅用钠平衡的变化或肾素 - 血管紧张素系统的活性来解释。
