The NAC family of transcription factors includes no apical meristem (NAM), transcription activator 1/2 (ATAF1/2), and cup-shaped cotyledon (CUC2) proteins, which are unique to plants, contributing significantly to their adaptation to environmental challenges. In the present study, we observed that the PvNAC52 protein is predominantly expressed in the cell membrane, cytoplasm, and nucleus. Overexpression of in strengthened plant resilience to salt, alkali, osmotic, and ABA stresses. PvNAC52 significantly ( < 0.05) reduced the degree of oxidative damage to cell membranes, proline content, and plant water loss by increasing the expression of , , , , , , and . Moreover, the expression of genes associated with abiotic stress responses, such as , , , , , , and , was enhanced by overexpression. A yeast one-hybrid assay showed that PvNAC52 specifically binds to the cis-acting elements ABRE (abscisic acid-responsive elements, ACGTG) within the promoter. This further suggests that PvNAC52 is responsible for the transcriptional modulation of abiotic stress response genes by identifying the core sequence, ACGTG. These findings provide a theoretical foundation for the further analysis of the targeted cis-acting elements and genes downstream of PvNAC52 in the common bean.