Parkes M J, Bassett J M
J Endocrinol. 1985 Jun;105(3):379-82. doi: 10.1677/joe.0.1050379.
Insulin, glucose, lactate and alpha-amino acid nitrogen concentrations were measured in the plasma of ewes and their hypophysectomized fetal lambs during intravenous infusions of GH, prolactin or saline into the fetus in utero. Prolactin and saline had no effect on mother or fetus. Infusion of GH at 1.2 mg/kg per day for 2 days or at 0.4 mg/kg per day for 4 days caused a sustained twofold increae in the level of insulin and a smaller, but sustained, increase in the level of glucose in fetal plasma. We suggest that GH antagonizes the action of insulin in the fetus. Glucose supplies to the fetal brain and placenta may be protected by such antagonism of insulin use during glucose shortage.
在向子宫内的胎儿静脉输注生长激素（GH）、催乳素或生理盐水期间，测定了母羊及其垂体切除的胎儿羔羊血浆中的胰岛素、葡萄糖、乳酸和α-氨基酸氮浓度。催乳素和生理盐水对母羊或胎儿均无影响。每天以1.2毫克/千克的剂量连续2天或每天以0.4毫克/千克的剂量连续4天输注生长激素，可使胎儿血浆中的胰岛素水平持续升高两倍，葡萄糖水平也有较小但持续的升高。我们认为，生长激素在胎儿体内拮抗胰岛素的作用。在葡萄糖短缺期间，胰岛素作用的这种拮抗作用可能会保护胎儿大脑和胎盘的葡萄糖供应。
