Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.
Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.
Int J Mol Sci. 2024 May 31;25(11):6046. doi: 10.3390/ijms25116046.
Pancreatic stone protein (PSP) is an acute-phase reactant mainly produced in response to stress. Its diagnostic and prognostic accuracy for several types of infection has been studied in several clinical settings. The aim of the current review was to assess all studies examining a possible connection of pancreatic stone protein levels with the severity and possible complications of patients diagnosed with infection. We performed a systematic search in PubMed, Scopus, the Cochrane Library and Clinicaltrials.gov to identify original clinical studies assessing the role of pancreatic stone protein in the diagnosis and prognosis of infectious diseases. We identified 22 eligible studies. Ten of them provided diagnostic aspects, ten studies provided prognostic aspects, and another two studies provided both diagnostic and prognostic information. The majority of the studies were performed in an intensive care unit (ICU) setting, five studies were on patients who visited the emergency department (ED), and three studies were on burn-injury patients. According to the literature, pancreatic stone protein has been utilized in patients with different sites of infection, including pneumonia, soft tissue infections, intra-abdominal infections, urinary tract infections, and sepsis. In conclusion, PSP appears to be a useful point-of-care biomarker for the ED and ICU due to its ability to recognize bacterial infections and sepsis early. Further studies are required to examine PSP's kinetics and utility in specific populations and conditions.
胰腺结石蛋白 (PSP) 是一种急性期反应物，主要是对压力作出反应而产生。其在几种感染类型中的诊断和预后准确性已在多个临床环境中进行了研究。本综述的目的是评估所有研究，以确定胰腺结石蛋白水平与感染患者的严重程度和可能发生的并发症之间是否存在关联。我们在 PubMed、Scopus、Cochrane 图书馆和 Clinicaltrials.gov 中进行了系统搜索，以确定评估胰腺结石蛋白在诊断和预测传染性疾病中的作用的原始临床研究。我们确定了 22 项符合条件的研究。其中 10 项提供了诊断方面的信息，10 项提供了预后方面的信息，另外两项研究则提供了诊断和预后信息。大多数研究是在重症监护病房 (ICU) 环境中进行的，5 项研究是在急诊科就诊的患者中进行的，3 项研究是在烧伤患者中进行的。根据文献，胰腺结石蛋白已在不同部位感染的患者中得到应用，包括肺炎、软组织感染、腹腔内感染、尿路感染和败血症。总之，由于 PSP 能够早期识别细菌感染和败血症，因此它似乎是急诊科和 ICU 中有用的即时护理生物标志物。需要进一步研究来检查 PSP 在特定人群和情况下的动力学和实用性。
