Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Int J Mol Sci. 2024 May 31;25(11):6094. doi: 10.3390/ijms25116094.
Cancer has been one of the most problematic health issues globally. Typically, all cancers share a common characteristic or cancer hallmark, such as sustaining cell proliferation, evading growth suppressors, and enabling replicative immortality. Indeed, cell cycle regulation in cancer is often found to be dysregulated, leading to an increase in aggressiveness. These dysregulations are partly due to the aberrant cellular signaling pathway. In recent years, circular RNAs (circRNAs) have been widely studied and classified as one of the regulators in various cancers. Numerous studies have reported that circRNAs antagonize or promote cancer progression through the modulation of cell cycle regulators or their associated signaling pathways, directly or indirectly. Mostly, circRNAs are known to act as microRNA (miRNA) sponges. However, they also hold additional mechanisms for regulating cellular activity, including protein binding, RNA-binding protein (RBP) recruitment, and protein translation. This review will discuss the current knowledge of how circRNAs regulate cell cycle-related proteins through the abovementioned mechanisms in different cancers.
癌症一直是全球最具挑战性的健康问题之一。通常，所有癌症都具有共同的特征或癌症标志，例如维持细胞增殖、逃避生长抑制剂和实现复制性永生。事实上，癌症中的细胞周期调控经常失调，导致侵袭性增加。这些失调部分归因于细胞信号通路的异常。近年来，环状 RNA（circRNA）已被广泛研究，并被归类为各种癌症的调节剂之一。大量研究报道，circRNA 通过调节细胞周期调节剂或其相关信号通路，直接或间接地拮抗或促进癌症进展。大多数情况下，circRNA 被认为是 microRNA（miRNA）的海绵。然而，它们还具有其他调节细胞活性的机制，包括蛋白结合、RNA 结合蛋白（RBP）募集和蛋白质翻译。本综述将讨论当前的知识，即 circRNA 通过上述机制在不同癌症中如何调节细胞周期相关蛋白。
