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槲皮素通过调节肠道微生物群缓解小檗碱诱导的便秘：功效及分子机制。

Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota.

机构信息

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.

School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

出版信息

Int J Mol Sci. 2024 Jun 5;25(11):6228. doi: 10.3390/ijms25116228.

DOI:10.3390/ijms25116228
PMID:38892414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11173111/
Abstract

Berberine (BBR) is used to treat cancer, inflammatory conditions, and so on. But the side effects of BBR causing constipation should not be ignored. In clinical application, the combination of Lour. (AVL) and BBR can relieve it. However, the effective ingredients and molecular mechanism of AVL in relieving constipation are not clear. A small intestine propulsion experiment was conducted in constipated mice to screen active ingredients of AVL. We further confirmed the molecular mechanism of action of the active ingredient on BBR-induced constipation. Quercetin (QR) was found to be the effective ingredient of AVL in terms of relieving constipation. QR can efficiently regulate the microbiota in mice suffering from constipation. Moreover, QR significantly raised the levels of substance P and motilin while lowering those of 5-hydroxytryptamine and vasoactive intestinal peptide; furthermore, it also increased the protein expression levels of calmodulin, myosin light-chain kinase, and myosin light chain. The use of QR in combination with BBR has an adverse effect-reducing efficacy. The study provides new ideas and possibilities for the treatment of constipation induced by BBR.

摘要

小檗碱（BBR）被用于治疗癌症、炎症等疾病。但 BBR 引起便秘的副作用不容忽视。在临床应用中，黄连（AVL）与 BBR 的联合使用可以缓解便秘。然而，AVL 缓解便秘的有效成分及分子机制尚不清楚。本研究通过建立便秘小鼠的小肠推进实验，筛选 AVL 的活性成分。进一步证实了该活性成分对 BBR 诱导的便秘的作用机制。研究发现槲皮素（QR）是 AVL 缓解便秘的有效成分。QR 可有效调节便秘小鼠的肠道菌群。此外，QR 可显著提高 P 物质和胃动素水平，降低 5-羟色胺和血管活性肠肽水平，同时增加钙调蛋白、肌球蛋白轻链激酶和肌球蛋白轻链的蛋白表达水平。QR 与 BBR 联合使用具有减效作用。本研究为 BBR 诱导的便秘治疗提供了新的思路和可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/b12544a35057/ijms-25-06228-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/8dcfaabc2b78/ijms-25-06228-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/b7c85a5396b9/ijms-25-06228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/813377bff926/ijms-25-06228-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/d7a2dc50489e/ijms-25-06228-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/826baa79a980/ijms-25-06228-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/e9234d9ef041/ijms-25-06228-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/be81603e2317/ijms-25-06228-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/4810a6e0055c/ijms-25-06228-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/b12544a35057/ijms-25-06228-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/8dcfaabc2b78/ijms-25-06228-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/b7c85a5396b9/ijms-25-06228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/813377bff926/ijms-25-06228-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/d7a2dc50489e/ijms-25-06228-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/826baa79a980/ijms-25-06228-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/e9234d9ef041/ijms-25-06228-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/be81603e2317/ijms-25-06228-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/4810a6e0055c/ijms-25-06228-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312c/11173111/b12544a35057/ijms-25-06228-g008.jpg

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引用本文的文献

[1]
Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence.

Eur J Med Res. 2025-6-12

[2]
Obesity: pathophysiology and therapeutic interventions.

Mol Biomed. 2025-4-25

本文引用的文献

[1]
The Repurposing of Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs: An Urgent Challenge for Aprepitant.

Int J Mol Sci. 2023-11-3

[2]
Borderline hyperlipidemia preventive management with Berberine PL in asymptomatic prevention of early atherosclerosis.

Minerva Gastroenterol (Torino). 2024-3

[3]
Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Nutr. 2023-10

[4]
Prevalence and Burden of Illness of Rome IV Chronic Idiopathic Constipation, Opioid-Induced Constipation, and Opioid-Exacerbated Constipation in the United States.

Am J Gastroenterol. 2023-11-1

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[Mechanism of Xiaoer Chiqiao Qingre Granules in clearing heat and removing food stagnation in suckling rats with fever and food accumulation based on metabolomics].

Zhongguo Zhong Yao Za Zhi. 2023-2

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Potential Targets in Constipation Research: A Review.

Curr Drug Targets. 2023

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The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation.

Bioengineered. 2021-12

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Genome Med. 2021-8-9

[9]
Congenital ablation of reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis.

Am J Physiol Endocrinol Metab. 2021-3-1

[10]
Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial.

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