Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
Nutrients. 2024 May 27;16(11):1638. doi: 10.3390/nu16111638.
L. () is an evergreen shrub (Anacardiaceae family) primarily found in the Mediterranean region. The plant has been thoroughly characterized, resulting in a high concentration of bioactive compounds as flavonoids and phenolics. Moreover, was revealed to possess a great nutritional and industrial importance because of its variety of biological activities, including antibacterial, anti-inflammatory, anti-atherogenic and antioxidant properties. Many of its beneficial health properties and applications date back to antiquity, and the European Medicines Agency officially acknowledged it as an herbal medicinal product. Indeed, it is widely employed in conventional medicine to treat several diseases, including type 2 diabetes (T2D). On this basis, this review aims to summarize and describe the chemical composition of different parts of the plant and highlight the potential of , focusing on its antidiabetic activities. The plant kingdom is drawing increasing attention because of its complexity of natural molecules in the research of novel bioactive compounds for drug development. In this context, demonstrated several in vitro and in vivo antidiabetic effects, acting upon many therapeutic T2D targets. Therefore, the information available in this review highlighted the multitarget effects of and its great potential in T2D treatment.
欧洲李（L.）是一种常绿灌木（漆树科），主要分布在地中海地区。该植物已被充分研究，含有高浓度的生物活性化合物，如类黄酮和酚类。此外，由于其具有多种生物活性，包括抗菌、抗炎、抗动脉粥样硬化和抗氧化作用，具有重要的营养价值和工业价值。其许多有益健康的特性和应用可以追溯到古代，欧洲药品管理局正式将其确认为草药药物。事实上，它在传统医学中被广泛用于治疗多种疾病，包括 2 型糖尿病（T2D）。基于此，本综述旨在总结和描述植物不同部位的化学成分，并重点介绍 的潜在用途，特别是其抗糖尿病活性。由于植物王国的天然分子结构复杂，在研究新型生物活性化合物以开发药物方面受到越来越多的关注。在这种情况下， 已被证明具有多种体外和体内抗糖尿病作用，可作用于许多治疗 2 型糖尿病的靶点。因此，本综述中提供的信息突出了 的多靶点作用及其在 2 型糖尿病治疗中的巨大潜力。
