Departamento de Farmacia, Universidad Nacional de Colombia, Av. Carrera 30 # 45-03 Edif. 450, Bogotá 111321, Colombia.
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Rua João Pio Duarte Silva, 241, Sala G301, Florianópolis 88037-000, SC, Brazil.
Nutrients. 2024 May 29;16(11):1669. doi: 10.3390/nu16111669.
Type 2 diabetes mellitus (T2DM) is a major global public health concern, prompting the ongoing search for new treatment options. Medicinal plants have emerged as one such alternative. Our objective was to evaluate the antidiabetic effect of an extract from the leaves of (). For this purpose, T2DM was first induced in mice using a high-fat diet and low doses of streptozotocin. Subsequently, an aqueous extract or an ethanolic extract of leaves was administered for 21 days. The following relevant results were found: fasting blood glucose levels were reduced by up to 41%, and by 29% after an oral glucose overload. The homeostasis model assessment of insulin resistance (HOMA-IR) was reduced by 59%. Histopathologically, better preservation of pancreatic tissue was observed. Regarding oxidative stress parameters, there was an increase of up to 48% in superoxide dismutase (SOD), an increase in catalase (CAT) activity by 35% to 80%, and a decrease in lipid peroxidation (MDA) by 35% to 80% in the liver, kidney, or pancreas. Lastly, regarding the lipid profile, triglycerides (TG) were reduced by up to 30%, total cholesterol (TC) by 35%, and low-density lipoproteins (LDL) by up to 32%, while treatments increased high-density lipoproteins (HDL) by up to 35%. With all the above, we can conclude that leaves showed antihyperglycemic, hypolipidemic, and antioxidant effects, making this species promising for the treatment of T2DM.
2 型糖尿病（T2DM）是一个重大的全球公共卫生关注点，促使人们不断寻求新的治疗选择。药用植物已成为一种选择。我们的目的是评估（）叶提取物的抗糖尿病作用。为此，首先使用高脂肪饮食和低剂量链脲佐菌素诱导 T2DM 小鼠。随后，给予叶的水提物或醇提物 21 天。发现了以下相关结果：空腹血糖水平降低了 41%，口服葡萄糖负荷后降低了 29%。胰岛素抵抗的稳态模型评估（HOMA-IR）降低了 59%。组织病理学上，观察到胰腺组织得到了更好的保护。关于氧化应激参数，超氧化物歧化酶（SOD）增加了 48%，过氧化氢酶（CAT）活性增加了 35%至 80%，肝、肾或胰腺中的脂质过氧化（MDA）减少了 35%至 80%。最后，关于血脂谱，甘油三酯（TG）降低了 30%，总胆固醇（TC）降低了 35%，低密度脂蛋白（LDL）降低了 32%，而治疗增加了高密度脂蛋白（HDL）35%。综上所述，我们可以得出结论，（）叶具有降血糖、降血脂和抗氧化作用，因此有望用于治疗 T2DM。
