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营养、维生素 D 和髋部骨折前后老年患者的钙及其对骨骼肌肉系统的影响:叙事性综述。

Nutrition, Vitamin D, and Calcium in Elderly Patients before and after a Hip Fracture and Their Impact on the Musculoskeletal System: A Narrative Review.

机构信息

Bone Metabolic Diseases Unit, Department of Experimental and Clinical Biomedical Sciences, University Hospital of Florence, University of Florence, 50134 Florence, Italy.

Division of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.

出版信息

Nutrients. 2024 Jun 5;16(11):1773. doi: 10.3390/nu16111773.

Abstract

Hip fractures are a major health issue considerably impacting patients' quality of life and well-being. This is particularly evident in elderly subjects, in which the decline in bone and muscle mass coexists and predisposes individuals to fall and fracture. Among interventions to be implemented in hip fractured patients, the assessment and management of nutritional status is pivotal, particularly in subjects older than 65. Nutrition plays a central role in both primary and secondary preventions of fracture. An adequate protein intake improves muscle mass and strength and the intestinal absorption of calcium. Other nutrients with recognized beneficial effects on bone health are calcium, vitamins D, K, and C, potassium, magnesium, folate, and carotenoids. With reference to calcium, results from longitudinal studies showed that the consumption of dairy foods has a protective role against fractures. Moreover, the most recent systematic reviews and meta-analyses and one umbrella review demonstrated that the combination of calcium and vitamin D supplementation significantly reduces hip fracture risk, with presumed higher efficacy in older and institutionalized subjects. Owing to these reasons, the adequate intake of calcium, vitamin D, protein, and other macro and micronutrients has been successfully implemented in the Fracture Liaison Services (FLSs) that represent the most reliable model of management for hip fracture patients. In this narrative review, papers (randomized controlled trials, prospective and intervention studies, and systematic reviews) retrieved by records from three different databases (PubMed, Embase, and Medline) have been analyzed, and the available information on the screening, assessment, and management of nutritional and vitamin D status and calcium intake in patients with hip fractures is presented along with specific prevention and treatment measures.

摘要

髋部骨折是一个重大的健康问题,严重影响患者的生活质量和幸福感。这在老年人中尤为明显,他们的骨量和肌肉量下降,容易导致跌倒和骨折。在髋部骨折患者中实施的干预措施中,评估和管理营养状况至关重要,尤其是 65 岁以上的患者。营养在骨折的一级和二级预防中都起着核心作用。充足的蛋白质摄入可以改善肌肉量和力量,促进钙的肠道吸收。其他对骨骼健康有公认有益作用的营养素包括钙、维生素 D、K 和 C、钾、镁、叶酸和类胡萝卜素。关于钙,纵向研究的结果表明,食用乳制品对骨折有保护作用。此外,最近的系统评价和荟萃分析以及一篇伞状综述表明,钙和维生素 D 联合补充显著降低髋部骨折风险,在年龄较大和住院的患者中效果更高。由于这些原因,钙、维生素 D、蛋白质和其他宏量和微量营养素的充足摄入已成功纳入骨折联络服务(Fracture Liaison Services,FLSs),这是髋部骨折患者最可靠的管理模式。在这篇叙述性综述中,分析了从三个不同数据库(PubMed、Embase 和 Medline)中检索到的论文(随机对照试验、前瞻性和干预研究以及系统评价),并介绍了髋部骨折患者营养和维生素 D 状况以及钙摄入的筛查、评估和管理方面的现有信息,以及具体的预防和治疗措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9461/11174536/1ca56d6e36ad/nutrients-16-01773-g001.jpg

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