Lőrincz Aba, Nudelman Hermann, Lamberti Anna Gabriella, Garami András, Tiborcz Krisztina Adrienne, Kovács Tamás Zoltán, Józsa Gergő
Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary.
Division of Pediatric Surgery, Traumatology, Urology and Pediatric Otolaryngology, Department of Pediatrics, Medical School, University of Pécs, 7 József Attila Street, H7623 Pécs, Hungary.
J Clin Med. 2024 May 24;13(11):3074. doi: 10.3390/jcm13113074.
In burn care, achieving swift healing with minimal complications remains paramount. This investigation assesses the role of polyhexamethylene biguanide (PHMB) in managing pediatric superficial partial-thickness burns, focusing on the effects of various patient-specific factors on recovery. Through a retrospective analysis of 27 pediatric cases treated with PHMB, we evaluated the impact of age, burn size, dressing frequency, treatment delay, cold therapy application, and analgesic usage on the time until reepithelialization (TTRE). The majority of patients benefited from early cold therapy, yet only 1 in 3 patients received analgesics. A mean healing time of 8.78 (SD: 2.64) days was observed, with the extent of the burn showing a strong correlation (r: 0.63) to TTRE. Most treatments were managed outpatient, evidenced by a negligible average hospital stay (0.96 days), with recorded no complications. Our findings endorse PHMB as a promising treatment for superficial second-degree burns in young patients, due to the observed stable and rapid wound closure without the association of increased risks. Continued exploration into the optimal application of prehospital interventions and the comprehensive benefits of PHMB in pediatric burn management is necessary. Future research should assess long-term outcomes, including functionality, scar quality, and patient satisfaction.
在烧伤护理中，以最小的并发症实现快速愈合仍然至关重要。本研究评估了聚六亚甲基双胍（PHMB）在治疗小儿浅二度烧伤中的作用，重点关注各种患者特定因素对恢复的影响。通过对27例接受PHMB治疗的儿科病例进行回顾性分析，我们评估了年龄、烧伤面积、换药频率、治疗延迟、冷疗应用和镇痛药物使用对创面再上皮化时间（TTRE）的影响。大多数患者从早期冷疗中受益，但只有三分之一的患者使用了镇痛药。观察到平均愈合时间为8.78（标准差：2.64）天，烧伤程度与TTRE显示出很强的相关性（r：0.63）。大多数治疗在门诊进行，平均住院时间很短（0.96天），且无并发症记录。我们的研究结果支持PHMB作为治疗年轻患者浅二度烧伤的一种有前景的治疗方法，因为观察到创面愈合稳定且迅速，且没有增加风险。有必要继续探索院前干预措施的最佳应用以及PHMB在小儿烧伤管理中的综合益处。未来的研究应评估长期结果，包括功能、瘢痕质量和患者满意度。
