Çalapkorur Bekir, Demirci Erkan, Baran Oğuzhan, Ulusoy Ersin Kasım, Koçer Derya, Demirelli Selami, Gök Mustafa, Şimşek Ziya
Department of Cardiology, Kayseri City Education and Research Hospital, Kayseri 38080, Turkey.
Department of Neurology, Ankara City Education and Research Hospital, Ankara 38080, Turkey.
J Clin Med. 2024 May 29;13(11):3175. doi: 10.3390/jcm13113175.
Paroxysmal atrial fibrillation (PAF) is an important cause that is thought main potential factor in Embolic stroke of undetermined source (ESUS). Extended Holter ECG is an expensive and time-consuming examination. It needs another tools for predicting PAF in ESUS patients. In this study, serum galectin-3 levels, ECG parameters (PR interval, P wave time and P wave peak time) LA volume index, LA global peak strain and atrial electromechanical conduction time values were investigated for predicting PAF. 150 patients with ESUS and 30 volunteers for the control group were recruited to study. 48-72 h Holter ECG monitoring was used for detecting PAF. Patients were divided into two groups (ESUS + PAF and ESUS-PAF) according to the development of PAF in Holter ECG monitoring. 30 patients with ESUS whose Holter ECG monitoring showed PAF, were recruited to the ESUS + PAF group. Other 120 patients with ESUS were recruited to the ESUS-PAF group. PA lateral, PA septum, and PA tricuspid were higher in the ESUS + PAF group ( < 0.001 for all). Serum galectin-3 levels were significantly higher in ESUS + PAF than in ESUS-PAF and control groups (479.0 pg/mL ± 435.8 pg/mL, 297.8 pg/mL ± 280.3 pg/mL, and 125.4 ± 87.0 pg/mL, < 0.001, respectively). Serum galectin-3 levels were significantly correlated with LAVI, PA lateral, and global peak LA strain (r = 0.246, = 0.001, = 0.158, = 0.035, r = -0.176, = 0.018, respectively). Serum galectin-3 levels is found higher in ESUS patients which developed PAF and Serum galectin-3 levels are associated LA adverse remodeling in patients with ESUS.
阵发性心房颤动（PAF）被认为是不明原因栓塞性卒中（ESUS）的一个重要病因及主要潜在因素。动态心电图检查费用高昂且耗时。需要其他工具来预测ESUS患者的PAF。在本研究中，对血清半乳糖凝集素-3水平、心电图参数（PR间期、P波时限和P波峰时限）、左心房容积指数、左心房整体峰值应变和心房机电传导时间值进行了研究，以预测PAF。招募了150例ESUS患者和30名志愿者作为对照组进行研究。采用48 - 72小时动态心电图监测来检测PAF。根据动态心电图监测中PAF的发生情况，将患者分为两组（ESUS + PAF组和ESUS - PAF组）。动态心电图监测显示PAF的30例ESUS患者被纳入ESUS + PAF组。其他120例ESUS患者被纳入ESUS - PAF组。ESUS + PAF组的PA外侧、PA间隔和PA三尖瓣更高（均P < 0.001）。ESUS + PAF组的血清半乳糖凝集素-3水平显著高于ESUS - PAF组和对照组（分别为479.0 pg/mL ± 435.8 pg/mL、297.8 pg/mL ± 280.3 pg/mL和125.4 ± 87.0 pg/mL，P均< 0.001）。血清半乳糖凝集素-3水平与左心房容积指数、PA外侧和左心房整体峰值应变显著相关（r分别为0.246，P = 0.001；r = 0.158，P = 0.035；r = -0.176，P = 0.018）。发现发生PAF的ESUS患者血清半乳糖凝集素-3水平较高，且血清半乳糖凝集素-3水平与ESUS患者的左心房不良重塑有关。
