Mahmoud Ahmed M, Moustafa Amr, Day Carter, Ahmed Mohamed E, Zeina Wael, Marzouk Usama M, Basourakos Spyridon, Haloi Rimki, Mahon Mindie, Muniz Miguel, Childs Daniel S, Orme Jacob J, Riaz Irbaz Bin, Kendi A Tuba, Stish Bradley J, Davis Brian J, Kwon Eugene D, Andrews Jack R
Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
Cancers (Basel). 2024 May 30;16(11):2080. doi: 10.3390/cancers16112080.
Prostate cancer lung metastasis represents a clinical conundrum due to its implications for advanced disease progression and the complexities it introduces in treatment planning. As the disease progresses to distant sites such as the lung, the clinical management becomes increasingly intricate, requiring tailored therapeutic strategies to address the unique characteristics of metastatic lesions. This review seeks to synthesize the current state of knowledge surrounding prostate cancer metastasis to the lung, shedding light on the diverse array of clinical presentations encountered, ranging from subtle radiological findings to overt symptomatic manifestations. By examining the diagnostic modalities utilized in identifying this metastasis, including advanced imaging techniques and histopathological analyses, this review aims to provide insights into the diagnostic landscape and the challenges associated with accurately characterizing lung metastatic lesions in prostate cancer patients. Moreover, this review delves into the nuances of therapeutic interventions employed in managing prostate cancer lung metastasis, encompassing systemic treatments such as hormonal therapies and chemotherapy, as well as metastasis-directed therapies including surgery and radiotherapy.
前列腺癌肺转移是一个临床难题,因为它意味着疾病进展到晚期,并且在治疗规划中引入了复杂性。随着疾病进展到远处部位如肺部,临床管理变得越来越复杂,需要定制治疗策略来应对转移病灶的独特特征。本综述旨在综合围绕前列腺癌肺转移的当前知识状态,阐明所遇到的各种临床表现,从细微的影像学发现到明显的症状表现。通过研究用于识别这种转移的诊断方法,包括先进的成像技术和组织病理学分析,本综述旨在深入了解诊断情况以及在准确表征前列腺癌患者肺转移病灶方面所面临的挑战。此外,本综述深入探讨了用于管理前列腺癌肺转移的治疗干预措施的细微差别,包括激素疗法和化疗等全身治疗,以及包括手术和放疗在内的转移灶定向治疗。