Iqbal Zohaib, Albuquerque Kevin, Chan Kimberly L
Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Cancers (Basel). 2024 Jun 5;16(11):2141. doi: 10.3390/cancers16112141.
This review article investigates the utilization of MRS in the setting of cervical cancer. A variety of different techniques have been used in this space including single-voxel techniques such as point-resolved spectroscopy (PRESS) and stimulated echo acquisition mode spectroscopy (STEAM). Furthermore, the experimental parameters for these acquisitions including field strength, repetition times (TR), and echo times (TE) vary greatly. This study critically examines eleven MRS studies that focus on cervical cancer. Out of the eleven studies, ten studies utilized PRESS acquisition, while the remaining study used STEAM acquisition. These studies generally showed that the choline signal is altered in cervical cancer (4/11 studies), the lipid signal is generally increased in cervical cancer or the lipid distribution is changed (5/11 studies), and that diffusion-weighted imaging (DWI) can quantitatively detect lower apparent diffusion coefficient (ADC) values in cervical cancer (2/11 studies). Two studies also investigated the role of MRS for monitoring treatment response and demonstrated mixed results regarding choline signal, and one of these studies showed increased lipid signal for non-responders. There are several new MRS technologies that have yet to be implemented for cervical cancer including advanced spectroscopic imaging and artificial intelligence, and those technologies are also discussed in the article.
这篇综述文章探讨了磁共振波谱（MRS）在宫颈癌中的应用。在这个领域已经使用了多种不同的技术，包括单体素技术，如点分辨光谱法（PRESS）和刺激回波采集模式光谱法（STEAM）。此外，这些采集的实验参数，包括场强、重复时间（TR）和回波时间（TE），差异很大。本研究批判性地审视了11项聚焦于宫颈癌的MRS研究。在这11项研究中，10项研究采用了PRESS采集，而其余1项研究使用了STEAM采集。这些研究总体上表明，宫颈癌中胆碱信号发生改变（4/11项研究），宫颈癌中脂质信号通常增加或脂质分布发生变化（5/11项研究），并且扩散加权成像（DWI）可以定量检测宫颈癌中较低的表观扩散系数（ADC）值（2/11项研究）。两项研究还调查了MRS在监测治疗反应中的作用，并在胆碱信号方面显示出混合结果，其中一项研究显示无反应者的脂质信号增加。有几种新的MRS技术尚未应用于宫颈癌，包括先进的光谱成像和人工智能，本文也对这些技术进行了讨论。
